Linked Life Data

19806792

Source:http://linkedlifedata.com/resource/pubmed/id/19806792

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11-12
pubmed:dateCreated
2009-10-7
pubmed:abstractText
The effect of B cell-specific MLV integration site-1 (Bmi-1) RNA interference (RNAi)-mediated inhibition of Bmi-1 expression on the proliferation, apoptosis, and invasiveness of human gastric carcinoma AGS cells was investigated. RT-PCR and Western blot analyses demonstrated that Bmi-1 expression and the Bmi-1 protein level were significantly decreased in Bmi-1 shRNA transfected AGS cells compared to untransfected and nonspecific shRNA transfected AGS cells. Bmi-1 RNAi-mediated inhibition of Bmi-1 expression significantly affected cell growth and invasiveness, and resulted in increased AGS cell apoptosis. This was not observed in untransfected and nonspecific shRNA transfected AGS cells. Inhibition of Bmi-1 expression in human gastric carcinoma cells affects cell proliferation and invasiveness.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0965-0407
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
613-20
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Knockdown of Bmi-1 impairs growth and invasiveness of human gastric carcinoma cells.
pubmed:affiliation
Department of Gastroenterology and Hubei Provincial Center of Clinical Study for Digestive Diseases, Zhongnan Hospital, the Key Laboratory of Allergy and Immune-related Diseases, Wuhan University School of Medicine, Wuhan, PR China. xiaojunzhongnan@163.com
pubmed:publicationType
Journal Article