Source:http://linkedlifedata.com/resource/pubmed/id/19805636
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2009-10-22
|
| pubmed:abstractText |
To focus on early cardiac and vascular autonomic dysfunction that might complicate type 1 diabetes mellitus in children, we planned an observational, cross-sectional study in a population of 93 young patients, under insulin treatment, subdivided in 2 age subgroups (children: 11.5+/-0.4 years; adolescents: 19.3+/-0.2 years). Time and frequency domain analysis of RR interval and systolic arterial pressure variability provided quantitative indices of the sympatho-vagal balance regulating the heart period, of the gain of cardiac baroreflex, and of the sympathetic vasomotor control. Sixty-eight children of comparable age served as a reference group. At rest, systolic arterial pressure and the power of its low-frequency component were greater in patients than in controls, particularly in children (14.0+/-2.3 versus 3.1+/-0.3 mm Hg2). Moreover, baroreflex gain was significantly reduced in both subgroups of patients. Standing induced similar changes in the autonomic profiles of controls and patients. A repeat study after 1 year showed a progression in low-frequency oscillations of arterial pressure and a shift toward low frequency in RR variability. Data in young patients with type 1 diabetes mellitus show a significant increase in arterial pressure, a reduced gain of the baroreflex regulation of the heart period, and an increase of the low-frequency component of systolic arterial pressure variability, suggestive of simultaneous impairment of vagal cardiac control and increases of sympathetic vasomotor regulation. A repeat study after 1 year shows a further increase of sympathetic cardiac and vascular modulation, suggesting early progression of the autonomic dysfunction.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1524-4563
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
54
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
987-94
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:19805636-Adolescent,
pubmed-meshheading:19805636-Age Distribution,
pubmed-meshheading:19805636-Analysis of Variance,
pubmed-meshheading:19805636-Autonomic Nervous System Diseases,
pubmed-meshheading:19805636-Baroreflex,
pubmed-meshheading:19805636-Blood Glucose,
pubmed-meshheading:19805636-Child,
pubmed-meshheading:19805636-Cross-Sectional Studies,
pubmed-meshheading:19805636-Diabetes Complications,
pubmed-meshheading:19805636-Diabetes Mellitus, Type 1,
pubmed-meshheading:19805636-Diabetic Angiopathies,
pubmed-meshheading:19805636-Diabetic Neuropathies,
pubmed-meshheading:19805636-Disease Progression,
pubmed-meshheading:19805636-Female,
pubmed-meshheading:19805636-Hemoglobin A, Glycosylated,
pubmed-meshheading:19805636-Humans,
pubmed-meshheading:19805636-Insulin,
pubmed-meshheading:19805636-Male,
pubmed-meshheading:19805636-Probability,
pubmed-meshheading:19805636-Prognosis,
pubmed-meshheading:19805636-Reference Values,
pubmed-meshheading:19805636-Risk Assessment,
pubmed-meshheading:19805636-Severity of Illness Index,
pubmed-meshheading:19805636-Sex Distribution,
pubmed-meshheading:19805636-Statistics, Nonparametric,
pubmed-meshheading:19805636-Time Factors
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Early progression of the autonomic dysfunction observed in pediatric type 1 diabetes mellitus.
|
| pubmed:affiliation |
Centro Ricerca Terapia Neurovegetativa, University of Milan, Milan, Italy.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|