Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
37
pubmed:dateCreated
2009-10-6
pubmed:abstractText
Abnormal processing of the amyloid precursor protein (APP) and beta-amyloid (Abeta) plaque accumulation are defining features of Alzheimer disease (AD), a genetically complex neurodegenerative disease that is characterized by progressive synapse loss and neuronal cell death. Abeta induces synaptic dysfunction in part by altering the endocytosis and trafficking of AMPA and NMDA receptors. Reelin is a neuromodulator that increases glutamatergic neurotransmission by signaling through the postsynaptic ApoE receptors Apoer2 and Vldlr and thereby potently enhances synaptic plasticity. Here we show that Reelin can prevent the suppression of long-term potentiation and NMDA receptors, which is induced by levels of Abeta comparable to those present in an AD-afflicted brain. This reversal is dependent upon the activation of Src family tyrosine kinases. At high concentrations of Abeta peptides, Reelin can no longer overcome the Abeta induced functional suppression and this coincides with a complete blockade of the Reelin-dependent phosphorylation of NR2 subunits. We propose a model in which Abeta, Reelin, and ApoE receptors modulate neurotransmission and thus synaptic stability as opposing regulators of synaptic gain control.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-10380922, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-10571240, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-10571241, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-10735401, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-11932745, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-12167620, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-12376533, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-12399581, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-12526740, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-12670422, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-1361685, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-14559149, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-14645539, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-14729980, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-15034556, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-15537891, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-15649697, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-16025111, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-16102539, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-16148228, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-16469784, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-17015223, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-17051202, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-17053810, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-17145504, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-17167084, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-17245412, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-17268505, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-17360908, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-17785178, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-17881522, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-18568035, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-19430527, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-8346443, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-8415756, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-8446617, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-9223338, http://linkedlifedata.com/resource/pubmed/commentcorrection/19805234-9600986
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Peptides, http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules, Neuronal, http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Low Density Lipoprotein..., http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases, http://linkedlifedata.com/resource/pubmed/chemical/amyloid beta-protein (1-42), http://linkedlifedata.com/resource/pubmed/chemical/amyloid beta-protein (25-35), http://linkedlifedata.com/resource/pubmed/chemical/reelin protein
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1091-6490
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15938-43
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:19805234-Alzheimer Disease, pubmed-meshheading:19805234-Amyloid beta-Peptides, pubmed-meshheading:19805234-Animals, pubmed-meshheading:19805234-Brain, pubmed-meshheading:19805234-Cell Adhesion Molecules, Neuronal, pubmed-meshheading:19805234-Extracellular Matrix Proteins, pubmed-meshheading:19805234-Hippocampus, pubmed-meshheading:19805234-Humans, pubmed-meshheading:19805234-Long-Term Potentiation, pubmed-meshheading:19805234-Low Density Lipoprotein Receptor-Related Protein-1, pubmed-meshheading:19805234-Mice, pubmed-meshheading:19805234-Mice, Inbred C57BL, pubmed-meshheading:19805234-Models, Neurological, pubmed-meshheading:19805234-Nerve Tissue Proteins, pubmed-meshheading:19805234-Neuronal Plasticity, pubmed-meshheading:19805234-Peptide Fragments, pubmed-meshheading:19805234-Receptors, N-Methyl-D-Aspartate, pubmed-meshheading:19805234-Recombinant Proteins, pubmed-meshheading:19805234-Serine Endopeptidases, pubmed-meshheading:19805234-Signal Transduction, pubmed-meshheading:19805234-Synapses, pubmed-meshheading:19805234-Synaptic Transmission
pubmed:year
2009
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