Linked Life Data

19803295

Source:http://linkedlifedata.com/resource/pubmed/id/19803295

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-10-6
pubmed:abstractText
Major congenital malformations occur in about 3% of newborn. Several studies have suggested that homozygosity for the C677T methylenetetrahydrofolate reductase (MTHFR) variant is a potential risk factor for neural tube defects (NTDs). It has been hypothesized that the maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant form of the enzyme. This association has not been found in some ethnic groups. In this study, we attempted to assess the association between NTDs and MTHFR C677T in Malaysian Malay population. Results show that MTHFR 677TT genotype was absent in both patient and control groups.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0300-5283
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
379-83
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
MTHFR C677T polymorphism as a risk factor of neural tube defects in Malay: a case control study.
pubmed:affiliation
Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Malaysia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't