Linked Life Data

19803130

Source:http://linkedlifedata.com/resource/pubmed/id/19803130

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-10-6
pubmed:abstractText
A comprehensive analytical method based on isotope dilution-liquid chromatography-tandem mass spectrometry has been developed for the determination of N-nitrosodiethanolamine in cosmetics. Water-soluble cosmetic samples were extracted with water. The extract was centrifuged, then the upper solution was cleaned up by an Oasis HLB solid phase extraction cartridge. Oil-soluble cosmetic samples were extracted by liquid-liquid partition with dichloromethane and water. Qualitative and quantitative analyses were carried out for the analyte under the multiple reaction monitoring (MRM) mode after the chromatographic separation on a Waters Atlantis T3 column (150 mm x 2.1 mm, 3 microm ). The quantitation was performed with deuterated N-nitrosodiethanolamine as internal standard. The limit of quantitation (LOQ) for N-nitrosodiethanolamine was 50 microg/kg. The mean recoveries were 89.1%-98.2% at the spiked levels of 50-250 microg/kg, with the intra-day precision less than 9% and the inter-day precision less than 11%. The method is suitable for the determination of NDELA in cosmetics.
pubmed:language
chi
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
May
pubmed:issn
1000-8713
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-7
pubmed:year
2009
pubmed:articleTitle
[Determination of N-nitrosodiethanolamine in cosmetics by isotope dilution-liquid chromatography-tandem mass spectrometry].
pubmed:affiliation
Chinese Academy of Inspection and Quarantine, Beijing 100123, China. maqiang1129@yahoo.com.cn
pubmed:publicationType
Journal Article, English Abstract