Source:http://linkedlifedata.com/resource/pubmed/id/19801831
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2009-10-5
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| pubmed:abstractText |
Effects of yokukansan (TJ-54) on memory disturbance and behavioral and psychological symptoms of dementia (BPSD) were investigated in thiamine-deficient (TD) rats which were produced by feeding a TD diet for 37 d. Daily oral administration of TJ-54 (0.5, 1.0 g/kg) ameliorated the memory disturbance, anxiety-like behavior, the increase in aggressive behaviors, the decrease in social behaviors, and several neurological symptoms including opisthotonus observed in TD rats, in a dose-dependent manner. In addition, histopathological examinations showed that TJ-54 inhibited the degeneration of neuronal and astroglial cells in the brain stem, hippocampus and cortex in TD rats. Microdialysis experiments showed that TJ-54 inhibited extracellular glutamate rise in the ventral posterior medial thalamus in TD rats. These results suggest that TJ-54 possesses the preventive or progress inhibitive effect against the development of memory disturbance and BPSD-like behaviors induced by the degeneration of neuronal and astroglial cells resulting from TD. TJ-54 may inhibit glutamate-mediated excitotoxicity as one of mechanisms.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
|
| pubmed:issn |
1347-5215
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| pubmed:author |
pubmed-author:IizukaSeiichiS,
pubmed-author:IkarashiYasushiY,
pubmed-author:ImamuraSachikoS,
pubmed-author:KannoHitomiH,
pubmed-author:KaseYoshioY,
pubmed-author:KawakamiZenjiZ,
pubmed-author:SekiguchiKyojiK,
pubmed-author:TakedaShuichiS,
pubmed-author:YamaguchiTakujiT,
pubmed-author:YuzuriharaMitsutoshiM
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| pubmed:issnType |
Electronic
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| pubmed:volume |
32
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1701-9
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| pubmed:meshHeading |
pubmed-meshheading:19801831-Aggression,
pubmed-meshheading:19801831-Angiosperms,
pubmed-meshheading:19801831-Animals,
pubmed-meshheading:19801831-Anxiety,
pubmed-meshheading:19801831-Astrocytes,
pubmed-meshheading:19801831-Behavior, Animal,
pubmed-meshheading:19801831-Brain,
pubmed-meshheading:19801831-Dementia,
pubmed-meshheading:19801831-Disease Models, Animal,
pubmed-meshheading:19801831-Disease Progression,
pubmed-meshheading:19801831-Dose-Response Relationship, Drug,
pubmed-meshheading:19801831-Drugs, Chinese Herbal,
pubmed-meshheading:19801831-Fungi,
pubmed-meshheading:19801831-Glutamic Acid,
pubmed-meshheading:19801831-Male,
pubmed-meshheading:19801831-Medicine, East Asian Traditional,
pubmed-meshheading:19801831-Medicine, Kampo,
pubmed-meshheading:19801831-Memory Disorders,
pubmed-meshheading:19801831-Neurons,
pubmed-meshheading:19801831-Phytotherapy,
pubmed-meshheading:19801831-Rats,
pubmed-meshheading:19801831-Rats, Wistar,
pubmed-meshheading:19801831-Social Behavior,
pubmed-meshheading:19801831-Thiamine Deficiency
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| pubmed:year |
2009
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| pubmed:articleTitle |
Effects of yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats.
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| pubmed:affiliation |
Tsumura Research Laboratories, Tsumura & Co., Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan. ikarashi_yasushi@mail.tsumura.co.jp
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| pubmed:publicationType |
Journal Article
|