19800987

Source:http://linkedlifedata.com/resource/pubmed/id/19800987

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007577, umls-concept:C0014257, umls-concept:C0086418, umls-concept:C0225336, umls-concept:C0332261, umls-concept:C1135918, umls-concept:C1280500
pubmed:issue	2
pubmed:dateCreated	2010-3-30
pubmed:abstractText	The goal of this study is to develop unique native endothelium mimicking nanomatrices and evaluate their effects on adhesion and spreading of human umbilical vein endothelial cells (HUVECs) and aortic smooth muscle cells (AoSMCs). These nanomatrices were developed by self-assembly of peptide amphiphiles (PAs) through a solvent evaporation technique. Three PAs, one containing the Tyr-Ile-Gly-Ser-Arg (YIGSR) ligand, the second containing the Val-Ala-Pro-Gly (VAPG) ligand, and a third without cell adhesive ligands, were developed. Cell adhesion and spreading were evaluated by a PicoGreen-DNA assay and live/dead assay, respectively. Our results show that PA-YIGSR significantly enhances HUVEC adhesion (26,704 +/- 2708), spreading (84 +/- 8%), and proliferation (50 +/- 2%) compared with that of other PAs. PA-VAPG and PA-YIGSR showed significantly greater AoSMC adhesion compared with that of PA-S. PA-VAPG also showed significantly greater spreading of AoSMCs (63 +/- 11%) compared with that of other PAs. Also, all the PAs showed significantly reduced platelet adhesion compared with that of collagen I (control). These findings would facilitate the development of novel vascular grafts, heart valves, and cell-based therapies for cardiovascular diseases. FROM THE CLINICAL EDITOR: The goal of this study was to develop unique native endothelium mimicking nanomatrices and evaluate their effects on adhesion and spreading of human umbilical vein endothelial cells (HUVECs) and aortic smooth muscle cells (AoSMCs). These nanomatrices were developed by self-assembly of peptide amphiphiles through a solvent evaporation technique. The findings are expected to facilitate the development of novel vascular grafts, heart valves, and cell based therapies for cardiovascular diseases.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/T32 EB004312-01A2, http://linkedlifedata.com/resource/pubmed/grant/T32EB004312
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-11372057, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-11835163, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-11860307, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-11920671, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-12081906, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-12684159, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-133627, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-14517884, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-15027844, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-15103405, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-15207463, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-15389489, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-16734483, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-1829082, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-1878448, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-1907272, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-2297480, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-2934816, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-8463322, http://linkedlifedata.com/resource/pubmed/commentcorrection/19800987-9189829
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101233142
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	1549-9642
pubmed:author	pubmed-author:AndersonJoel MJM, pubmed-author:AndukuriAdinarayanaA, pubmed-author:JunHo-WookHW, pubmed-author:KushwahaMeenakshiM, pubmed-author:MinorWill PWP
pubmed:copyrightInfo	Copyright 2010 Elsevier Inc. All rights reserved.
pubmed:issnType	Electronic
pubmed:volume	6
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	289-97
pubmed:dateRevised	2011-9-26
pubmed:meshHeading	pubmed-meshheading:19800987-Biomimetic Materials, pubmed-meshheading:19800987-Cell Adhesion, pubmed-meshheading:19800987-Cell Movement, pubmed-meshheading:19800987-Cells, Cultured, pubmed-meshheading:19800987-Endothelial Cells, pubmed-meshheading:19800987-Humans, pubmed-meshheading:19800987-Myocytes, Smooth Muscle, pubmed-meshheading:19800987-Nanostructures, pubmed-meshheading:19800987-Tissue Engineering
pubmed:year	2010
pubmed:articleTitle	Effect of endothelium mimicking self-assembled nanomatrices on cell adhesion and spreading of human endothelial cells and smooth muscle cells.
pubmed:affiliation	Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural