|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2009-10-5
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Multiple myeloma (MM) remains incurable despite novel therapies, suggesting the need for further identification of factors mediating tumorigenesis and drug resistance. Using both in vitro and in vivo MM xenograft models, we show that plasmacytoid dendritic cells (pDCs) in the bone marrow (BM) microenvironment both mediate immune deficiency characteristic of MM and promote MM cell growth, survival, and drug resistance. Microarray, cell signaling, cytokine profile, and immunohistochemical analysis delineate the mechanisms mediating these sequelae. Although pDCs are resistant to novel therapies, targeting toll-like receptors with CpG oligodeoxynucleotides both restores pDC immune function and abrogates pDC-induced MM cell growth. Our study therefore validates targeting pDC-MM interactions as a therapeutic strategy to overcome drug resistance in MM.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Boronic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/CPG-oligonucleotide,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/bortezomib
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1878-3686
|
|
pubmed:author |
pubmed-author:AndersonKenneth CKC,
pubmed-author:BandiMadhaviM,
pubmed-author:BianchiGiadaG,
pubmed-author:BrahmandamMohanM,
pubmed-author:CarrascoRubenR,
pubmed-author:ChauhanDharminderD,
pubmed-author:HideshimaTeruT,
pubmed-author:JayeDavid LDL,
pubmed-author:KumarShaji KSK,
pubmed-author:MitsiadesConstantineC,
pubmed-author:MunshiNikhilN,
pubmed-author:PodarKlausK,
pubmed-author:RajeNoopurN,
pubmed-author:RichardsonPaulP,
pubmed-author:SinghAjita VAV,
pubmed-author:TaiYu-TzuYT
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
6
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
309-23
|
|
pubmed:dateRevised |
2010-12-3
|
|
pubmed:meshHeading |
pubmed-meshheading:19800576-Animals,
pubmed-meshheading:19800576-Antineoplastic Agents,
pubmed-meshheading:19800576-Apoptosis,
pubmed-meshheading:19800576-Bone Marrow Cells,
pubmed-meshheading:19800576-Boronic Acids,
pubmed-meshheading:19800576-Case-Control Studies,
pubmed-meshheading:19800576-Cell Communication,
pubmed-meshheading:19800576-Cell Proliferation,
pubmed-meshheading:19800576-Cell Survival,
pubmed-meshheading:19800576-Chemotaxis,
pubmed-meshheading:19800576-Coculture Techniques,
pubmed-meshheading:19800576-Cytokines,
pubmed-meshheading:19800576-Dendritic Cells,
pubmed-meshheading:19800576-Drug Resistance, Neoplasm,
pubmed-meshheading:19800576-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19800576-Humans,
pubmed-meshheading:19800576-Immunophenotyping,
pubmed-meshheading:19800576-Mice,
pubmed-meshheading:19800576-Mice, SCID,
pubmed-meshheading:19800576-Multiple Myeloma,
pubmed-meshheading:19800576-Oligodeoxyribonucleotides,
pubmed-meshheading:19800576-Protease Inhibitors,
pubmed-meshheading:19800576-Proteasome Endopeptidase Complex,
pubmed-meshheading:19800576-Pyrazines,
pubmed-meshheading:19800576-Receptors, Immunologic,
pubmed-meshheading:19800576-Signal Transduction,
pubmed-meshheading:19800576-T-Lymphocytes,
pubmed-meshheading:19800576-Time Factors,
pubmed-meshheading:19800576-Toll-Like Receptors,
pubmed-meshheading:19800576-Transplantation, Heterologous,
pubmed-meshheading:19800576-Tumor Cells, Cultured
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target.
|
|
pubmed:affiliation |
The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Center for Myeloma Research, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. dharminder_chauhan@dfci.harvard.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
