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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-10-16
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pubmed:abstractText |
While many molecules involved in axon guidance have been identified, the cellular and molecular mechanisms by which these molecules regulate growth cone morphology during axon outgrowth remain to be elucidated. The actin cytoskeleton of the growth cone underlies the formation of lamellipodia and filopodia that control growth cone outgrowth and guidance. The role of the Arp2/3 complex in growth cone filopodia formation has been controversial, and other mechanisms of growth cone filopodia formation remain to be described.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1749-8104
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
38
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:19799769-Actin-Related Protein 2-3 Complex,
pubmed-meshheading:19799769-Animals,
pubmed-meshheading:19799769-Animals, Genetically Modified,
pubmed-meshheading:19799769-Axons,
pubmed-meshheading:19799769-Caenorhabditis elegans,
pubmed-meshheading:19799769-Caenorhabditis elegans Proteins,
pubmed-meshheading:19799769-Cell Movement,
pubmed-meshheading:19799769-Growth Cones,
pubmed-meshheading:19799769-Microfilament Proteins,
pubmed-meshheading:19799769-Mutation,
pubmed-meshheading:19799769-Nerve Tissue Proteins,
pubmed-meshheading:19799769-Neurons,
pubmed-meshheading:19799769-Pseudopodia,
pubmed-meshheading:19799769-Sensory Receptor Cells,
pubmed-meshheading:19799769-Time Factors,
pubmed-meshheading:19799769-Video Recording
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pubmed:year |
2009
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pubmed:articleTitle |
The Arp2/3 complex, UNC-115/abLIM, and UNC-34/Enabled regulate axon guidance and growth cone filopodia formation in Caenorhabditis elegans.
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pubmed:affiliation |
Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA. adnorris@ku.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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