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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-11-26
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pubmed:abstractText |
Genetic predisposition of nuclear factor-kappa B (NF-kappaB)-signaling pathways linking inflammation to hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) remains unresolved. We conducted a case-control study to determine the associations of the polymorphisms within the promoter regions of NFKB1 encoding NF-kappaB1 and NFKBIA encoding IkappaBalpha with the development of HCC. A total of 404 healthy controls, 482 non-HCC subjects with HBV infection and 202 patients with HCC were included. NFKB1 -94ATTG2 allele and GG allele in the 3'-untranslated region of NFKBIA were more prevalent in HCC patients than in the healthy controls. NFKBIA -826CT and NFKBIA -881AG allelic carriages were more prevalent in HCC patients than in the non-HCC subjects with HBV infection. The estimated haplotype frequency of NFKBIA promoter -881G-826T-519C was significantly higher in the patients with HCC than in the HBV-infected subjects without HCC (odds ratio = 3.142, P = 0.002). As compared with the HBV-infected subjects without HCC, NFKBIA -826 T and NFKBIA -881AG allelic carriages were only associated with HCC risk in the subjects with HBV genotype C. The association of NFKBIA -881AG allelic carriage with HCC risk was not affected by liver cirrhosis (LC) status, alanine aminotransferase level and hepatitis B e antigen status. By multivariate regression analysis, NFKB1 -94ATTG2, NFKBIA -826T, NFKBIA -881AG and HBV genotype C were independently associated with an increased risk of HCC. In conclusion, NFKB1 -94ATTG2 allele and haplotype -881G-826T-519C in NFKBIA promoter were associated with hepatocarcinogenesis. NFKBIA -826T and -881AG were associated with the risk of HCC in the subjects infected with HBV genotype C.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19797428-10454581,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19797428-9299585
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1460-2180
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pubmed:author |
pubmed-author:CaoGuangwenG,
pubmed-author:HeYongchaoY,
pubmed-author:LiChengzhongC,
pubmed-author:LiuShijianS,
pubmed-author:TanXiaojieX,
pubmed-author:WangHongyangH,
pubmed-author:XieJiaxinJ,
pubmed-author:YinJianhuaJ,
pubmed-author:ZhangHongweiH,
pubmed-author:ZhangQianQ,
pubmed-author:ZhaoJunJ
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pubmed:issnType |
Electronic
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1916-22
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:19797428-Adult,
pubmed-meshheading:19797428-Alleles,
pubmed-meshheading:19797428-Carcinoma, Hepatocellular,
pubmed-meshheading:19797428-Case-Control Studies,
pubmed-meshheading:19797428-Female,
pubmed-meshheading:19797428-Genetic Predisposition to Disease,
pubmed-meshheading:19797428-Haplotypes,
pubmed-meshheading:19797428-Hepatitis B,
pubmed-meshheading:19797428-Hepatitis B e Antigens,
pubmed-meshheading:19797428-Hepatitis B virus,
pubmed-meshheading:19797428-Humans,
pubmed-meshheading:19797428-I-kappa B Proteins,
pubmed-meshheading:19797428-Liver Cirrhosis,
pubmed-meshheading:19797428-Liver Neoplasms,
pubmed-meshheading:19797428-Male,
pubmed-meshheading:19797428-Middle Aged,
pubmed-meshheading:19797428-NF-kappa B p50 Subunit,
pubmed-meshheading:19797428-Odds Ratio,
pubmed-meshheading:19797428-Polymorphism, Genetic,
pubmed-meshheading:19797428-Promoter Regions, Genetic
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pubmed:year |
2009
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pubmed:articleTitle |
IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C.
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pubmed:affiliation |
Department of Epidemiology, the 1st Affiliated Hospital, Second Military Medical University, Shanghai 200433, People's Republic of China.
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