Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-2-4
pubmed:abstractText
Resveratrol is a natural occurring phytoalexin present in grapes and berries, that has been shown to have chemopreventive/therapeutic activity. But the precise mechanism of resveratrol involved in leukemia is not well understood. In this study, we examine its anti-leukemia effect both in vitro and in vivo. Our data indicate that resveratrol contributes to inhibiting growth, inducing apoptosis and cell cycle arrest in the three leukemia cell lines (Jurkat, SUP-B15, and Kasumi-1), and reducing the phosphorylation of STAT3, meanwhile modulating the expression of Bcl-2 and Bax. In vivo, resveratrol could prolong the life span of Kasumi-1-bearing mice, and attenuate the activity of STAT3. Taken altogether, this investigation focuses on signaling pathways involved in STAT3 by resveratrol and to delineate its molecular mechanisms underlying anti-leukemia effect.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1878-1705
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-25
pubmed:meshHeading
pubmed-meshheading:19796711-Animals, pubmed-meshheading:19796711-Antineoplastic Agents, pubmed-meshheading:19796711-Apoptosis, pubmed-meshheading:19796711-Cell Cycle, pubmed-meshheading:19796711-Cell Proliferation, pubmed-meshheading:19796711-Gene Expression Regulation, Leukemic, pubmed-meshheading:19796711-Humans, pubmed-meshheading:19796711-Jurkat Cells, pubmed-meshheading:19796711-Leukemia, T-Cell, pubmed-meshheading:19796711-Male, pubmed-meshheading:19796711-Mice, pubmed-meshheading:19796711-Mice, Inbred BALB C, pubmed-meshheading:19796711-Neoplasm Transplantation, pubmed-meshheading:19796711-Proto-Oncogene Proteins c-bcl-2, pubmed-meshheading:19796711-STAT3 Transcription Factor, pubmed-meshheading:19796711-Signal Transduction, pubmed-meshheading:19796711-Stilbenes, pubmed-meshheading:19796711-bcl-2-Associated X Protein
pubmed:year
2010
pubmed:articleTitle
Evaluation of anti-leukemia effect of resveratrol by modulating STAT3 signaling.
pubmed:affiliation
Tianjin Key Laboratory for Biomarkers of Occupational and Environmental Hazard, Medical College of Chinese People's Armed Police Force, Tianjin, PR China. tanli20042001@yahoo.com.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't