Source:http://linkedlifedata.com/resource/pubmed/id/19796452
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2010-5-31
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| pubmed:abstractText |
A retrospective study of clinical characteristics, outcome and prognostic factors of patients with cryptococcosis was undertaken in intensive care units (ICUs) of a medical centre for the period 2000-2005. Twenty-six patients with Cryptococcus neoformans var. grubii infection were identified (16 males, median age 58 years). The most frequent underlying diseases were liver cirrhosis (38.5%), diabetes mellitus (26.9%) and HIV infection (19.2%). The most frequently identified sites of infection were blood (61.5%), cerebrospinal fluid (38.5%) and airways (34.6%). The mean Acute Physiologic and Chronic Health Evaluation II score at ICU admission was 22.46. The ICU mortality rate in these patients was 73.1% (19/26) and there were a further two mortalities recorded after discharge from ICU, reaching a total mortality rate of 80.8% (21/26). Patients with ICU survival >2 weeks had lower rates of HIV infection (P=0.004), less use of inotropic agents during ICU stay (P<0.001) and lower white blood cell counts (P=0.01). After adjusting for clinical variables in the multivariate Cox regression model, diabetes and cryptococcal infection after ICU admission were independent predictors of good long-term prognosis (P=0.015) and HIV infectious status was associated with poor outcome (P=0.012).
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1469-4409
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
138
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1036-43
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| pubmed:meshHeading |
pubmed-meshheading:19796452-Ascites,
pubmed-meshheading:19796452-Cross Infection,
pubmed-meshheading:19796452-Cryptococcosis,
pubmed-meshheading:19796452-Cryptococcus neoformans,
pubmed-meshheading:19796452-Diabetes Complications,
pubmed-meshheading:19796452-Female,
pubmed-meshheading:19796452-HIV Infections,
pubmed-meshheading:19796452-Heart Diseases,
pubmed-meshheading:19796452-Humans,
pubmed-meshheading:19796452-Hypertension,
pubmed-meshheading:19796452-Intensive Care Units,
pubmed-meshheading:19796452-Kidney Diseases,
pubmed-meshheading:19796452-Liver Cirrhosis,
pubmed-meshheading:19796452-Lung Diseases,
pubmed-meshheading:19796452-Male,
pubmed-meshheading:19796452-Middle Aged,
pubmed-meshheading:19796452-Organ Transplantation,
pubmed-meshheading:19796452-Retrospective Studies,
pubmed-meshheading:19796452-Rheumatic Diseases
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| pubmed:year |
2010
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| pubmed:articleTitle |
Disseminated Cryptococcus neoformans var. grubii infections in intensive care units.
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| pubmed:affiliation |
Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin branch, Dou-Liou City, Taiwan.
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| pubmed:publicationType |
Journal Article
|