Source:http://linkedlifedata.com/resource/pubmed/id/19796242
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2009-10-2
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| pubmed:abstractText |
Leukemias are composed of a hierarchy of cells, only a fraction of which have stem cell-like properties and are capable of self-renewal. Mixed lineage leukemia (MLL) fusion proteins produced by translocations involving the MLL gene on chromosome 11q23 confer stem cell-like properties on committed hematopoietic progenitors. This provides an opportunity to assess changes in immunophenotype, gene expression, and epigenetic programs during the transition from a hematopoietic cell with minimal inherent self-renewal capability to cells capable of leukemic self-renewal.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1749-6632
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
1176
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
144-9
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| pubmed:meshHeading |
pubmed-meshheading:19796242-Animals,
pubmed-meshheading:19796242-Cell Transformation, Neoplastic,
pubmed-meshheading:19796242-Hematopoietic Stem Cells,
pubmed-meshheading:19796242-Histones,
pubmed-meshheading:19796242-Humans,
pubmed-meshheading:19796242-Leukemia, Myeloid, Acute,
pubmed-meshheading:19796242-Methylation,
pubmed-meshheading:19796242-Mice,
pubmed-meshheading:19796242-Myeloid-Lymphoid Leukemia Protein,
pubmed-meshheading:19796242-Neoplastic Stem Cells
|
| pubmed:year |
2009
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| pubmed:articleTitle |
Transformation from committed progenitor to leukemia stem cells.
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| pubmed:affiliation |
Division of Hematology/Oncology, Children's Hospital, Department of Pediatric Oncology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02215, USA.
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| pubmed:publicationType |
Journal Article
|