Linked Life Data

19795520

Source:http://linkedlifedata.com/resource/pubmed/id/19795520

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2009-10-28
pubmed:abstractText
Otoliths in bony fishes are involved in the function of the ear in the senses of balance and hearing. In a large-scale random in situ hybridization screen of genes expressed in the medaka developing ear, we identified starmaker-like (stm-l) gene, a novel homologue of zebrafish starmaker and human dentine sialo-phosphoprotein (dspp) gene. Despite the absence of sequence similarity between these genes, here we describe their similar genomic structure and expression patterns hinting for a conserved function. In medaka fry, stm-l is expressed in various organs such as otoliths, teeth, gills, and kidney. Additionally, our results provide evidence that stm-l is a putative downstream target gene of Pax2 transcription factor and Pax2 itself has a promoting function in otolith formation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1097-0177
pubmed:author
pubmed:copyrightInfo
Copyright 2009 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:volume
238
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2860-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Identification of starmaker-like in medaka as a putative target gene of Pax2 in the otic vesicle.
pubmed:affiliation
Max-Planck Institute of Immunobiology, Freiburg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't