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rdf:type |
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lifeskim:mentions |
umls-concept:C0022179,
umls-concept:C0025519,
umls-concept:C0043210,
umls-concept:C0205419,
umls-concept:C0237401,
umls-concept:C0279752,
umls-concept:C0521324,
umls-concept:C0805586,
umls-concept:C1280500,
umls-concept:C1706089,
umls-concept:C2756587
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pubmed:issue |
5
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pubmed:dateCreated |
2009-10-1
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pubmed:abstractText |
Soy-isoflavones may act as estrogenic agonists or antagonists depending on the endogenous hormone status. These clinical effects can be exerted variably in individuals by the metabolic ability to produce a more potent metabolite than precursors. The objective of this randomized, double-blind, placebo-controlled study was to investigate the skeletal effect of isoflavones according to their metabolic variability in premenopausal women. Volunteers were randomly assigned to receive either soy-extract isoflavones (n=32) or lactose (n=21) once a day for three menstrual cycles. After intervention, the urinary excretions of isoflavones and their metabolites were significantly higher in the soy group than in the placebo group and showed a large inter-individual variation. Women in the soy group were divided into subgroups according to their ability to excrete more potent metabolites. Serum osteocalcin and urine deoxypyridinoline showed a tendency to increase after a challenge in equol high-excretors. Serum osteocalcin concentration in the genistein high-excretors increased significantly after a challenge (P=0.04) but did not increase in either the placebo or genistein low-excretors. An estrogenic antagonistic effect of isoflavones on bone turnover was observed in premenopausal women who are able to produce more potent metabolites.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-10093753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-10839307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-10868692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-10966908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-10999783,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-11701680,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-12369794,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-12672914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-13680814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-15083317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-15533901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-16118406,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-17148567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-17577003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-6262113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-7662591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-8074062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-8691209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-8770469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-9217716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-9467531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-9751507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-9848502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794985-9848516
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1598-6357
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
867-73
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pubmed:meshHeading |
pubmed-meshheading:19794985-Adult,
pubmed-meshheading:19794985-Amino Acids,
pubmed-meshheading:19794985-Bone and Bones,
pubmed-meshheading:19794985-Double-Blind Method,
pubmed-meshheading:19794985-Estrogen Antagonists,
pubmed-meshheading:19794985-Female,
pubmed-meshheading:19794985-Humans,
pubmed-meshheading:19794985-Isoflavones,
pubmed-meshheading:19794985-Middle Aged,
pubmed-meshheading:19794985-Osteocalcin,
pubmed-meshheading:19794985-Premenopause
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pubmed:year |
2009
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pubmed:articleTitle |
Marked individual variation in isoflavone metabolism after a soy challenge can modulate the skeletal effect of isoflavones in premenopausal women.
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pubmed:affiliation |
Division of Endocrinology, Department of Internal Medicine, Cheil General Hospital and Women's Healthcare Center, Kwandong University School of Medicine, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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