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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1302
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pubmed:dateCreated |
1991-1-24
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pubmed:abstractText |
Hybrid cell lines derived from neonatal rat dorsal root ganglia neurons fused with the mouse neuroblastoma N18Tg2 exhibit sensory neuron-like properties not displayed by the parental neuroblastoma. These properties include an inward (depolarizing) current with a conductance increase in response to activation of a bradykinin receptor, an inward (depolarizing) current with a conductance increase in response to the sensory excitotoxin capsaicin, the expression of sensory neuropeptides (substance P, CGRP and somatostatin), the expression of phosphatidylinositol-anchored molecules including adhesion molecules of the immunoglobulin superfamily that can be regulated in serum-free culture by nerve growth factor (N-CAM, F-3 and Thy-1), and low permissivity to herpes simplex virus infection. These lines thus provide appropriate models for the study of mechanisms involved in nociceptor activation and the regulation of expression of sensory-neuron specific markers including neuropeptides.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0962-8452
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
241
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
187-94
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pubmed:dateRevised |
2005-4-8
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pubmed:meshHeading |
pubmed-meshheading:1979443-Animals,
pubmed-meshheading:1979443-Bradykinin,
pubmed-meshheading:1979443-Capsaicin,
pubmed-meshheading:1979443-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:1979443-Cell Differentiation,
pubmed-meshheading:1979443-Cell Fusion,
pubmed-meshheading:1979443-Cell Line,
pubmed-meshheading:1979443-Cell Transformation, Viral,
pubmed-meshheading:1979443-Electric Conductivity,
pubmed-meshheading:1979443-Ganglia, Spinal,
pubmed-meshheading:1979443-Hybrid Cells,
pubmed-meshheading:1979443-Mice,
pubmed-meshheading:1979443-Neuroblastoma,
pubmed-meshheading:1979443-Neurons, Afferent,
pubmed-meshheading:1979443-Neuropeptides,
pubmed-meshheading:1979443-Nociceptors,
pubmed-meshheading:1979443-Receptors, Bradykinin,
pubmed-meshheading:1979443-Receptors, Neurotransmitter,
pubmed-meshheading:1979443-Simplexvirus
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pubmed:year |
1990
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pubmed:articleTitle |
Novel cell lines display properties of nociceptive sensory neurons.
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pubmed:affiliation |
Sandoz Institute for Medical Research, London, U.K.
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pubmed:publicationType |
Journal Article
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