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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0026986,
umls-concept:C0030705,
umls-concept:C0038952,
umls-concept:C0185117,
umls-concept:C0205214,
umls-concept:C0205251,
umls-concept:C0439590,
umls-concept:C1419703,
umls-concept:C1515021,
umls-concept:C1521461,
umls-concept:C2911684
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pubmed:issue |
10
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pubmed:dateCreated |
2009-10-1
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pubmed:abstractText |
To further clarify the role of ribosomal protein S14 (RPS14) in myelodysplastic syndrome, we examined RPS14 transcription in bone marrow derived CD34+ cells from patients with non-5q- myelodysplastic syndrome and found a reduced expression of RPS14 in 51 of 72 (71%) patients. MDS patients with an intermediate-1 risk (INT-1) score according to the international prognostic scoring system and low RPS14 expression had a superior median overall survival of not reached versus 25 months compared to INT-1 patients with high RPS14 expression (p=0.0249). Using multivariate analysis, the RPS14 expression status was confirmed as an independent predictor for survival in INT-1 patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794090-12036901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794090-14586479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794090-17726160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794090-17890457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794090-17916100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794090-18202658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794090-18268278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794090-18271621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794090-18650472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794090-19794078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794090-7949083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794090-9058730
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1592-8721
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1453-5
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pubmed:meshHeading |
pubmed-meshheading:19794090-Adult,
pubmed-meshheading:19794090-Aged,
pubmed-meshheading:19794090-Aged, 80 and over,
pubmed-meshheading:19794090-Chromosome Aberrations,
pubmed-meshheading:19794090-Chromosomes, Human, Pair 5,
pubmed-meshheading:19794090-Female,
pubmed-meshheading:19794090-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19794090-Humans,
pubmed-meshheading:19794090-Male,
pubmed-meshheading:19794090-Middle Aged,
pubmed-meshheading:19794090-Myelodysplastic Syndromes,
pubmed-meshheading:19794090-Registries,
pubmed-meshheading:19794090-Ribosomal Proteins,
pubmed-meshheading:19794090-Survival Rate
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pubmed:year |
2009
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pubmed:articleTitle |
Low RPS14 expression is common in myelodysplastic syndromes without 5q- aberration and defines a subgroup of patients with prolonged survival.
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pubmed:affiliation |
Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Duesseldorf Moorenstrasse 5, 40225 Duesseldorf, Germany. Akos.Czibere@med.uni-duesseldorf.de
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pubmed:publicationType |
Journal Article,
Comparative Study
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