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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-12-30
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pubmed:abstractText |
Mutations in the HNF1A gene are the most common cause of maturity-onset diabetes of the young (MODY). There is a substantial variation in the age at diabetes diagnosis, even within families where diabetes is caused by the same mutation. We investigated the hypothesis that common polygenic variants that predispose to type 2 diabetes might account for the difference in age at diagnosis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-10868881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-11272211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-12453975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-12453976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-12574234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-12882939,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-17212604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-17293876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-17463246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-17463248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-17463249,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-18437351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-18952314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-18971436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-18976728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-8866553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-9075818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19794065-9472859
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1939-327X
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pubmed:author |
pubmed-author:ColcloughKevinK,
pubmed-author:EllardSianS,
pubmed-author:FraylingTimothy MTM,
pubmed-author:HattersleyAndrew TAT,
pubmed-author:HertelJens KJK,
pubmed-author:JohanssonStefanS,
pubmed-author:Lango AllenHanaH,
pubmed-author:MolvenAndersA,
pubmed-author:NjølstadPål RPR,
pubmed-author:RaederHelgeH,
pubmed-author:ShieldsBeverleyB,
pubmed-author:WeedonMichael NMN
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pubmed:issnType |
Electronic
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
266-71
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pubmed:dateRevised |
2011-7-19
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pubmed:meshHeading |
pubmed-meshheading:19794065-Adolescent,
pubmed-meshheading:19794065-Adult,
pubmed-meshheading:19794065-Age of Onset,
pubmed-meshheading:19794065-Child,
pubmed-meshheading:19794065-Child, Preschool,
pubmed-meshheading:19794065-Diabetes Mellitus, Type 2,
pubmed-meshheading:19794065-Exons,
pubmed-meshheading:19794065-Family,
pubmed-meshheading:19794065-Female,
pubmed-meshheading:19794065-Genetic Predisposition to Disease,
pubmed-meshheading:19794065-Genetic Variation,
pubmed-meshheading:19794065-Great Britain,
pubmed-meshheading:19794065-Hepatocyte Nuclear Factor 1-alpha,
pubmed-meshheading:19794065-Humans,
pubmed-meshheading:19794065-Male,
pubmed-meshheading:19794065-Middle Aged,
pubmed-meshheading:19794065-Mutation,
pubmed-meshheading:19794065-Norway,
pubmed-meshheading:19794065-Risk Assessment,
pubmed-meshheading:19794065-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.
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pubmed:affiliation |
Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, U.K. hana.langoallen@pms.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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