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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1991-1-23
|
| pubmed:abstractText |
The apolipoprotein B gene is subject to mutations that may be important in coronary heart diseases. We have used polymerase chain reaction and denaturing gradient gel electrophoresis to characterize a single nucleotide substitution in the apolipoprotein B gene. This mutation affects amino acid 4311 of the protein and converts asparagine to serine. It was found in 24% of the 81 unrelated individuals analyzed. Moreover, another mutation was detected by sequencing in a single individual.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0340-6717
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
86
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
91-3
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1979313-Apolipoproteins B,
pubmed-meshheading:1979313-Base Sequence,
pubmed-meshheading:1979313-DNA,
pubmed-meshheading:1979313-Electrophoresis,
pubmed-meshheading:1979313-Humans,
pubmed-meshheading:1979313-Molecular Sequence Data,
pubmed-meshheading:1979313-Mutation,
pubmed-meshheading:1979313-Oligonucleotide Probes,
pubmed-meshheading:1979313-Polymerase Chain Reaction,
pubmed-meshheading:1979313-Polymorphism, Restriction Fragment Length
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Detection by denaturing gradient gel electrophoresis of a new polymorphism in the apolipoprotein B gene.
|
| pubmed:affiliation |
CNRS UPR 8402, Institut de Biologie, Montpellier, France.
|
| pubmed:publicationType |
Journal Article
|