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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-11-30
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pubmed:abstractText |
The lethality of prostate cancer is due to the continuous growth of cancer initiating cells (CICs) which are often stimulated by androgen receptor (AR) signaling. However, the underlying molecular mechanism(s) for such AR-mediated growth stimulation are not fully understood. Such mechanisms may involve cancer cell-dependent induction of tumor stromal cells to produce paracrine growth factors or could involve cancer cell autonomous autocrine and/or intracellular AR signaling pathways.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-10100708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-10212269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-10503993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-10950116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-11313721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-11431338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-11507082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-11861374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-11948964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-12044015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-12539223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-12843129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-14607213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-14689591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-15368473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-15378523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-15781983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-16230388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-16322242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-16368782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-16951173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-17015840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-17387277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-17426117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-17510410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-17597113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-17638891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-18075739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-18268494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-18593950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-19047148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-19182515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-7513416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-8674060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19790235-9699659
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1097-0045
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2009 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
90-9
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pubmed:dateRevised |
2011-7-19
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pubmed:meshHeading |
pubmed-meshheading:19790235-Animals,
pubmed-meshheading:19790235-Autocrine Communication,
pubmed-meshheading:19790235-Cell Line, Tumor,
pubmed-meshheading:19790235-Cell Proliferation,
pubmed-meshheading:19790235-Cell Transformation, Neoplastic,
pubmed-meshheading:19790235-Extracellular Space,
pubmed-meshheading:19790235-Humans,
pubmed-meshheading:19790235-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:19790235-Intracellular Fluid,
pubmed-meshheading:19790235-Male,
pubmed-meshheading:19790235-Mice,
pubmed-meshheading:19790235-Mice, Nude,
pubmed-meshheading:19790235-Neoplastic Stem Cells,
pubmed-meshheading:19790235-Prostatic Neoplasms,
pubmed-meshheading:19790235-Protein Binding,
pubmed-meshheading:19790235-Receptors, Androgen,
pubmed-meshheading:19790235-Signal Transduction,
pubmed-meshheading:19790235-Tumor Markers, Biological
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pubmed:year |
2010
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pubmed:articleTitle |
Cell-autonomous intracellular androgen receptor signaling drives the growth of human prostate cancer initiating cells.
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pubmed:affiliation |
Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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