Linked Life Data

1979009

Source:http://linkedlifedata.com/resource/pubmed/id/1979009

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-1-16
pubmed:abstractText
The cardiovascular effects of bolus doses of doxacurium 0.037 mg kg-1 were compared with those following equipotent doses of pancuronium (0.09 mg kg-1) and vecuronium (0.075 mg kg-1) and with those following high-dose doxacurium (0.075 mg kg-1), in patients with coronary artery disease. Anaesthetic technique comprised premedication with lorazepam, papaveretum and hyoscine, induction with diazepam, fentanyl, thiopentone, atropine and suxamethonium, and the trachea was intubated. At least 20 min later, during stable nitrous oxide in oxygen anaesthesia, a single bolus of neuromuscular blocking drug was administered and the effects measured at 1, 5 and 10 min. There was a small decrease in heart rate following doxacurium 0.075 mg kg-1, but no other significant or dose-related changes in mean heart rate, arterial pressure or cardiac index with doxacurium. Similar results were found following vecuronium, but the reduction in heart rate was more pronounced. In contrast, significant increases in mean arterial pressure, heart rate and cardiac index occurred after pancuronium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0007-0912
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
480-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Cardiovascular effects of doxacurium, pancuronium and vecuronium in anaesthetized patients presenting for coronary artery bypass surgery.
pubmed:affiliation
Anaesthetics Unit, London Hospital Medical College, Whitechapel.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't