19790071

Source:http://linkedlifedata.com/resource/pubmed/id/19790071

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0005516, umls-concept:C0012634, umls-concept:C0024141, umls-concept:C0282554, umls-concept:C0441655, umls-concept:C0681836
pubmed:issue	10
pubmed:dateCreated	2009-10-14
pubmed:abstractText	Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by unpredictable flares of disease activity and irreversible damage to multiple organ systems. An earlier study showed that SLE patients carrying an interferon (IFN) gene expression signature in blood have elevated serum levels of IFN-regulated chemokines. These chemokines were associated with more-severe and active disease and showed promise as SLE disease activity biomarkers. This study was designed to validate IFN-regulated chemokines as biomarkers of SLE disease activity in 267 SLE patients followed up longitudinally.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/AR-43727, http://linkedlifedata.com/resource/pubmed/grant/M01-RR-00052, http://linkedlifedata.com/resource/pubmed/grant/N01-AR-1-2256, http://linkedlifedata.com/resource/pubmed/grant/R01 AR043727-11
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0370605
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers, http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL19, http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2, http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL10, http://linkedlifedata.com/resource/pubmed/chemical/Interferons
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0004-3591
pubmed:author	pubmed-author:BaechlerEmily CEC, pubmed-author:BatliwallaFranak MFM, pubmed-author:BauerJason WJW, pubmed-author:BehrensTimothy WTW, pubmed-author:GregersenPeter KPK, pubmed-author:KoeuthThearithT, pubmed-author:Panoskaltsis-MortariAngelaA, pubmed-author:PetriMichelleM, pubmed-author:SlatteryCatherineC, pubmed-author:WilsonJosephJ
pubmed:issnType	Print
pubmed:volume	60
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3098-107
pubmed:dateRevised	2011-9-26
pubmed:meshHeading	pubmed-meshheading:19790071-Adult, pubmed-meshheading:19790071-Biological Markers, pubmed-meshheading:19790071-Chemokine CCL19, pubmed-meshheading:19790071-Chemokine CCL2, pubmed-meshheading:19790071-Chemokine CXCL10, pubmed-meshheading:19790071-Female, pubmed-meshheading:19790071-Follow-Up Studies, pubmed-meshheading:19790071-Humans, pubmed-meshheading:19790071-Interferons, pubmed-meshheading:19790071-Longitudinal Studies, pubmed-meshheading:19790071-Lupus Erythematosus, Systemic, pubmed-meshheading:19790071-Male, pubmed-meshheading:19790071-Multivariate Analysis, pubmed-meshheading:19790071-Prospective Studies, pubmed-meshheading:19790071-Severity of Illness Index, pubmed-meshheading:19790071-Signal Transduction
pubmed:year	2009
pubmed:articleTitle	Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: a validation study.
pubmed:affiliation	University of Minnesota, Minneapolis, MN 55455, USA.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural, Validation Studies