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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2009-10-14
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pubmed:abstractText |
Autologous chondrocyte implantation requires expansion of cells ex vivo, leading to dedifferentiation of chondrocytes (loss of aggrecan and type II collagen to the profit of type I and type III collagens). Several approaches have been described for redifferentiation of these cells. Among them, low oxygen tension has been exploited to restore the differentiated chondrocyte phenotype, but molecular mechanisms of this process remain unclear. However, under conditions of hypoxia, one of the major factors involved is hypoxia-inducible factor 1alpha (HIF-1alpha). The purpose of this study was to investigate the role of HIF-1alpha during human chondrocyte redifferentiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aggrecans,
http://linkedlifedata.com/resource/pubmed/chemical/COL2A1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/COL3A1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type III,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/SOX9 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/SOX9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/alpha 2(I) collagen,
http://linkedlifedata.com/resource/pubmed/chemical/collagen type I, alpha 1 chain
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3038-48
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pubmed:meshHeading |
pubmed-meshheading:19790048-Adult,
pubmed-meshheading:19790048-Aged,
pubmed-meshheading:19790048-Aged, 80 and over,
pubmed-meshheading:19790048-Aggrecans,
pubmed-meshheading:19790048-Cell Differentiation,
pubmed-meshheading:19790048-Cell Hypoxia,
pubmed-meshheading:19790048-Cells, Cultured,
pubmed-meshheading:19790048-Chondrocytes,
pubmed-meshheading:19790048-Collagen,
pubmed-meshheading:19790048-Collagen Type I,
pubmed-meshheading:19790048-Collagen Type II,
pubmed-meshheading:19790048-Collagen Type III,
pubmed-meshheading:19790048-Humans,
pubmed-meshheading:19790048-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:19790048-Middle Aged,
pubmed-meshheading:19790048-SOX9 Transcription Factor
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pubmed:year |
2009
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pubmed:articleTitle |
Hypoxia-inducible factor 1alpha inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1alpha-dependent redifferentiation of chondrocytes.
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pubmed:affiliation |
University of Caen Lower Normandy, IFR 146 ICORE, Caen, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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