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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2009-10-2
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pubmed:abstractText |
Tumor antigen-loaded dendritic cells (DC) are believed to activate antitumor immunity by stimulating T cells, and CTL-associated antigen 4 (CTLA4)-blocking antibodies should release a key negative regulatory pathway on T cells. The combination was tested in a phase I clinical trial in patients with advanced melanoma.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Blocking,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/CP-675,206,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cancer Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/MART-1 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/MLANA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BewL KLK,
pubmed-author:ChmielowskiBartoszB,
pubmed-author:CochranAlistair JAJ,
pubmed-author:Comin-AnduixBegoñaB,
pubmed-author:EconomouJames SJS,
pubmed-author:GlaspyJohn AJA,
pubmed-author:Gomez-NavarroJesusJ,
pubmed-author:KUOH YHY,
pubmed-author:MarincolaFrancesco MFM,
pubmed-author:McCannelTara ATA,
pubmed-author:OchoaMaria TeresaMT,
pubmed-author:OsegueraDenise KDK,
pubmed-author:RibasAntoniA,
pubmed-author:SejaElizabethE,
pubmed-author:StraatsmaBradley RBR,
pubmed-author:VillanuevaArturoA,
pubmed-author:WangEnaE,
pubmed-author:de la RochaPilarP
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6267-76
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19789309-Adult,
pubmed-meshheading:19789309-Aged,
pubmed-meshheading:19789309-Antibodies, Blocking,
pubmed-meshheading:19789309-Antibodies, Monoclonal,
pubmed-meshheading:19789309-Antigens, CD,
pubmed-meshheading:19789309-Antigens, Neoplasm,
pubmed-meshheading:19789309-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:19789309-CTLA-4 Antigen,
pubmed-meshheading:19789309-Cancer Vaccines,
pubmed-meshheading:19789309-Combined Modality Therapy,
pubmed-meshheading:19789309-Dendritic Cells,
pubmed-meshheading:19789309-Dose-Response Relationship, Drug,
pubmed-meshheading:19789309-Female,
pubmed-meshheading:19789309-Humans,
pubmed-meshheading:19789309-Immunotherapy, Adoptive,
pubmed-meshheading:19789309-K562 Cells,
pubmed-meshheading:19789309-MART-1 Antigen,
pubmed-meshheading:19789309-Male,
pubmed-meshheading:19789309-Melanoma,
pubmed-meshheading:19789309-Middle Aged,
pubmed-meshheading:19789309-Neoplasm Metastasis,
pubmed-meshheading:19789309-Neoplasm Proteins,
pubmed-meshheading:19789309-Peptide Fragments
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pubmed:year |
2009
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pubmed:articleTitle |
Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma.
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pubmed:affiliation |
Department of Medicine, Division of Hematology/Oncology, University of California at Los Angeles, Los Angeles, California 90095-1782, USA. aribas@mednet.ucla.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I,
Research Support, N.I.H., Extramural
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