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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-11-2
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pubmed:abstractText |
Murine Prickle1 and Prickle2 belong to the planar cell polarity genes. Prickle2 but not Prickle1 gene expression was induced in C1300 neuroblastoma cells during neurite-like process formation induced by retinoic acid (RA). Over-expression of Prickle1 or Prickle2 in C1300 cells induced striking neurite-like process formation in the absence of RA. Since Prickle binds to Dishevelled (Dvl) to induce its degradation in Drosophila, we examined the participation of Dvl protein in the neurite-like process formation of C1300 cells. Upon induction of the neurite-like process formation, the amount of Dvl1 protein decreased. Prickle1 and Prickle2 could associate with Dvl1 and over-expression of Prickle1 or Prickle2 resulted in the reduction of Dvl1 protein in C1300 cells. Furthermore, over-expression of Dvl1 in C1300 cells prevented the neurite-like process formation induced by Prickle1 or Prickle2 over-expression. Thus, Prickle1 and Prickle2 promote neurite-like process formation of C1300 cells via the Dvl1 dependent mechanism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/LIM Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Prickle1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Prickle2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/dishevelled proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1872-7972
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
467
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6-10
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19788910-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:19788910-Animals,
pubmed-meshheading:19788910-Carrier Proteins,
pubmed-meshheading:19788910-Cell Differentiation,
pubmed-meshheading:19788910-Cell Line,
pubmed-meshheading:19788910-Cell Line, Tumor,
pubmed-meshheading:19788910-Cells, Cultured,
pubmed-meshheading:19788910-Cerebellum,
pubmed-meshheading:19788910-Humans,
pubmed-meshheading:19788910-LIM Domain Proteins,
pubmed-meshheading:19788910-Membrane Proteins,
pubmed-meshheading:19788910-Mice,
pubmed-meshheading:19788910-Nerve Tissue Proteins,
pubmed-meshheading:19788910-Neurites,
pubmed-meshheading:19788910-Neurons,
pubmed-meshheading:19788910-Phosphoproteins,
pubmed-meshheading:19788910-RNA, Messenger,
pubmed-meshheading:19788910-Signal Transduction,
pubmed-meshheading:19788910-Transfection
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pubmed:year |
2009
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pubmed:articleTitle |
Prickle promotes neurite outgrowth via the Dishevelled dependent pathway in C1300 cells.
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pubmed:affiliation |
Biomedical Research Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba 260-8670, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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