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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-10-28
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pubmed:abstractText |
Many cystic fibrosis (CF)-associated mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channels affect CFTR-activated HCO(3)(-) transport more than Cl(-) transport. Targeting the CFTR HCO(3)(-) conductance, if possible, may therefore be of major therapeutic benefit. In the present study, we examined the effects of genistein and forskolin on duodenal mucosal HCO(3)(-) and Cl(-) secretion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1476-5381
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
158
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1313-21
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pubmed:dateRevised |
2010-11-2
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pubmed:meshHeading |
pubmed-meshheading:19788494-Animals,
pubmed-meshheading:19788494-Anions,
pubmed-meshheading:19788494-Bicarbonates,
pubmed-meshheading:19788494-Chlorides,
pubmed-meshheading:19788494-Cystic Fibrosis Transmembrane Conductance Regulator,
pubmed-meshheading:19788494-Duodenum,
pubmed-meshheading:19788494-Forskolin,
pubmed-meshheading:19788494-Genistein,
pubmed-meshheading:19788494-Intestinal Mucosa,
pubmed-meshheading:19788494-Ion Transport,
pubmed-meshheading:19788494-Mice,
pubmed-meshheading:19788494-Mice, Knockout,
pubmed-meshheading:19788494-Mutation
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pubmed:year |
2009
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pubmed:articleTitle |
Differential activation of the HCO(3)(-) conductance through the cystic fibrosis transmembrane conductance regulator anion channel by genistein and forskolin in murine duodenum.
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pubmed:affiliation |
Department of Gastroenterology, Affiliated Hospital, Zunyi Medical College, Zunyi, China. tuobiguang@yahoo.com.cn
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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