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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
33
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pubmed:dateCreated |
2009-11-20
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pubmed:abstractText |
Previous studies in non-small-cell lung cancer (NSCLC) have demonstrated a wide variation in responsiveness to epidermal growth factor receptor (EGFR) -targeting agents and in genetic aberrancies of the EGFR pathway according to ethnic background, most notably a higher frequency of activating EGFR mutations among East-Asian patients. We investigated the frequency of EGFR pathway aberrancies among African American patients with NSCLC, for whom limited information presently exists.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1527-7755
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pubmed:author |
pubmed-author:BoggonTitus JTJ,
pubmed-author:CappuzzoFedericoF,
pubmed-author:ChengJinJ,
pubmed-author:CliffordBradleyB,
pubmed-author:EisenbergRosanaR,
pubmed-author:FranklinWilbur AWA,
pubmed-author:FuPingfuP,
pubmed-author:HalmosBalazsB,
pubmed-author:HamdanAyadA,
pubmed-author:HirschFred RFR,
pubmed-author:LeidnerRom SRS,
pubmed-author:SkokanMargaretM,
pubmed-author:Varella-GarciaMarileilaM
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pubmed:issnType |
Electronic
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pubmed:day |
20
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5620-6
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pubmed:meshHeading |
pubmed-meshheading:19786660-Administration, Oral,
pubmed-meshheading:19786660-Adult,
pubmed-meshheading:19786660-African Americans,
pubmed-meshheading:19786660-Aged,
pubmed-meshheading:19786660-Aged, 80 and over,
pubmed-meshheading:19786660-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:19786660-Case-Control Studies,
pubmed-meshheading:19786660-DNA Mutational Analysis,
pubmed-meshheading:19786660-European Continental Ancestry Group,
pubmed-meshheading:19786660-Female,
pubmed-meshheading:19786660-Follow-Up Studies,
pubmed-meshheading:19786660-Genetic Predisposition to Disease,
pubmed-meshheading:19786660-Humans,
pubmed-meshheading:19786660-In Situ Hybridization, Fluorescence,
pubmed-meshheading:19786660-Lung Neoplasms,
pubmed-meshheading:19786660-Male,
pubmed-meshheading:19786660-Middle Aged,
pubmed-meshheading:19786660-Multivariate Analysis,
pubmed-meshheading:19786660-Mutation,
pubmed-meshheading:19786660-Neoplasm Staging,
pubmed-meshheading:19786660-Probability,
pubmed-meshheading:19786660-Quinazolines,
pubmed-meshheading:19786660-Receptor, Epidermal Growth Factor,
pubmed-meshheading:19786660-Risk Assessment,
pubmed-meshheading:19786660-ras Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
Genetic abnormalities of the EGFR pathway in African American Patients with non-small-cell lung cancer.
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pubmed:affiliation |
Departments of Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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