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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-11-17
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pubmed:abstractText |
In this study, application of a dual absorbance/fluorescence assay to a chemical library screen identified several previously unknown inhibitors of mycobacteria. In addition, growth conditions had a significant effect on the activity profile of the library. Some inhibitors such as Se-methylselenocysteine were detected only when screening was performed under nutrient-limited culture conditions as opposed to nutrient-rich culture conditions. We propose that multiple culture condition library screening is required for complete inhibitory profiling and for maximal antimycobacterial compound detection.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-10707260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-10768986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-11929527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-12011001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-12591871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-14638465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-15194159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-15942015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-16325529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-17451884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-18471060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-18471061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-18827575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-6225771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-8655555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-8707053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-8900060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-9145860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-9820531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19786608-9864340
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1098-6596
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5279-83
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria.
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pubmed:affiliation |
School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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