Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2009-10-5
pubmed:abstractText
Chronic inflammatory airway diseases including asthma are characterized by immune dysfunction to inhaled allergens. Our previous studies demonstrated that T cell priming to inhaled allergens requires LPS, which is ubiquitously present in household dust allergens. In this study, we evaluated the role of vascular endothelial growth factor (VEGF) in the development of T cell priming and its polarization to Th1 or Th17 cells when exposed to LPS-contaminated allergens. An asthma mouse model was induced by airway sensitization with LPS-contaminated allergens and then challenged with allergens alone. Therapeutic intervention was performed during allergen sensitization. The present study showed that lung inflammation induced by sensitization with LPS-contaminated allergens was decreased in mice with homozygous disruption of the IL-17 gene; in addition, allergen-specific Th17 immune response was abolished in IL-6 knockout mice. Meanwhile, in vivo production of VEGF was up-regulated by airway exposure of LPS. In addition, airway sensitization of allergen plus recombinant VEGF induced both type 1 and type 17 Th cell (Th1 and Th17) responses. Th1 and Th17 responses induced by airway sensitization with LPS-contaminated allergens were blocked by treatment with a pan-VEGF receptor (VEGFR; VEGFR-1 plus VEGFR-2) inhibitor during sensitization. These effects were accompanied by inhibition of the production of Th1 and Th17 polarizing cytokines, IL-12p70 and IL-6, respectively. These findings indicate that VEGF produced by LPS plays a key role in activation of naive T cells and subsequent polarization to Th1 and Th17 cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Allergens, http://linkedlifedata.com/resource/pubmed/chemical/Indoles, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6, http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides, http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles, http://linkedlifedata.com/resource/pubmed/chemical/SU 5416, http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A, http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor..., http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor..., http://linkedlifedata.com/resource/pubmed/chemical/vascular endothelial growth factor...
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1550-6606
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
183
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5113-20
pubmed:dateRevised
2010-7-26
pubmed:meshHeading
pubmed-meshheading:19786548-Allergens, pubmed-meshheading:19786548-Animals, pubmed-meshheading:19786548-Apoptosis, pubmed-meshheading:19786548-Asthma, pubmed-meshheading:19786548-Immunity, Active, pubmed-meshheading:19786548-Immunity, Innate, pubmed-meshheading:19786548-Indoles, pubmed-meshheading:19786548-Inflammation, pubmed-meshheading:19786548-Interleukin-12, pubmed-meshheading:19786548-Interleukin-17, pubmed-meshheading:19786548-Interleukin-6, pubmed-meshheading:19786548-Lipopolysaccharides, pubmed-meshheading:19786548-Lung, pubmed-meshheading:19786548-Mice, pubmed-meshheading:19786548-Mice, Inbred BALB C, pubmed-meshheading:19786548-Mice, Knockout, pubmed-meshheading:19786548-Ovalbumin, pubmed-meshheading:19786548-Protein Kinase Inhibitors, pubmed-meshheading:19786548-Pyrroles, pubmed-meshheading:19786548-T-Lymphocytes, Helper-Inducer, pubmed-meshheading:19786548-Th1 Cells, pubmed-meshheading:19786548-Vascular Endothelial Growth Factor A, pubmed-meshheading:19786548-Vascular Endothelial Growth Factor Receptor-1, pubmed-meshheading:19786548-Vascular Endothelial Growth Factor Receptor-2
pubmed:year
2009
pubmed:articleTitle
Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways.
pubmed:affiliation
Department of Life Science, POSTECH Biotech Center, Pohang University of Science and Technology, Pohang, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural