| pubmed-article:19786077 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19786077 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:19786077 | lifeskim:mentions | umls-concept:C0039493 | lld:lifeskim |
| pubmed-article:19786077 | lifeskim:mentions | umls-concept:C0014912 | lld:lifeskim |
| pubmed-article:19786077 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:19786077 | lifeskim:mentions | umls-concept:C0021376 | lld:lifeskim |
| pubmed-article:19786077 | lifeskim:mentions | umls-concept:C1155551 | lld:lifeskim |
| pubmed-article:19786077 | lifeskim:mentions | umls-concept:C1709694 | lld:lifeskim |
| pubmed-article:19786077 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19786077 | pubmed:dateCreated | 2009-11-16 | lld:pubmed |
| pubmed-article:19786077 | pubmed:abstractText | The mitogen-activated protein kinase/extracellular regulated kinase (MAPK/ERK) pathway plays a key role in mediating estrogen actions in the brain and neuronal sensitization during inflammation. Estrogen status is a risk factor in chronic temporomandibular muscle/joint (TMJ) disorders; however, the basis for this relationship is not known. The present study tested the hypothesis that estrogen status acts through the MAPK/ERK signaling pathway to alter TMJ nociceptive processing. Single TMJ-responsive neurons were recorded in laminae I-II at the spinomedullary (Vc/C(1-2)) junction in naïve ovariectomized (OvX) female rats treated for 2 days with high-dose (20 microg/day; HE2) or low-dose estradiol (2 microg/day; LE2) and after chronic inflammation of the TMJ region by complete Freund's adjuvant for 12-14 days. Intra-TMJ injection of ATP (1 mM) was used to activate Vc/C(1-2) neurons. The MAPK/ERK inhibitor (PD98059, 0.01-1 mM) was applied topically to the dorsal Vc/C(1-2) surface at the site of recording 10 min prior to each ATP stimulus. In naïve HE2 rats, low-dose PD98059 caused a maximal inhibition of ATP-evoked activity, whereas even high doses had only minor effects on units in LE2 rats. By contrast, after chronic TMJ inflammation, PD98059 produced a marked and similar dose-related inhibition of ATP-evoked activity in HE2 and LE2 rats. These results suggested that E2 status and chronic inflammation acted, at least in part, through a common MAPK/ERK-dependent signaling pathway to enhance TMJ nociceptive processing by laminae I-II neurons at the spinomedullary junction region. | lld:pubmed |
| pubmed-article:19786077 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19786077 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19786077 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19786077 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19786077 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19786077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19786077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19786077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19786077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19786077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19786077 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19786077 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19786077 | pubmed:issn | 1873-7544 | lld:pubmed |
| pubmed-article:19786077 | pubmed:author | pubmed-author:TashiroAA | lld:pubmed |
| pubmed-article:19786077 | pubmed:author | pubmed-author:OkamotoKK | lld:pubmed |
| pubmed-article:19786077 | pubmed:author | pubmed-author:BereiterD ADA | lld:pubmed |
| pubmed-article:19786077 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19786077 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:19786077 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:19786077 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19786077 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19786077 | pubmed:pagination | 1813-20 | lld:pubmed |
| pubmed-article:19786077 | pubmed:dateRevised | 2011-4-28 | lld:pubmed |
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| pubmed-article:19786077 | pubmed:meshHeading | pubmed-meshheading:19786077... | lld:pubmed |
| pubmed-article:19786077 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19786077 | pubmed:articleTitle | Chronic inflammation and estradiol interact through MAPK activation to affect TMJ nociceptive processing by trigeminal caudalis neurons. | lld:pubmed |
| pubmed-article:19786077 | pubmed:affiliation | Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, 18214 Moos Tower, Minneapolis, 515 Delaware Street SE, Minneapolis, MN 55455, USA. tashi004@umn.edu | lld:pubmed |
| pubmed-article:19786077 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19786077 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
