Source:http://linkedlifedata.com/resource/pubmed/id/19786077
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2009-11-16
|
| pubmed:abstractText |
The mitogen-activated protein kinase/extracellular regulated kinase (MAPK/ERK) pathway plays a key role in mediating estrogen actions in the brain and neuronal sensitization during inflammation. Estrogen status is a risk factor in chronic temporomandibular muscle/joint (TMJ) disorders; however, the basis for this relationship is not known. The present study tested the hypothesis that estrogen status acts through the MAPK/ERK signaling pathway to alter TMJ nociceptive processing. Single TMJ-responsive neurons were recorded in laminae I-II at the spinomedullary (Vc/C(1-2)) junction in naïve ovariectomized (OvX) female rats treated for 2 days with high-dose (20 microg/day; HE2) or low-dose estradiol (2 microg/day; LE2) and after chronic inflammation of the TMJ region by complete Freund's adjuvant for 12-14 days. Intra-TMJ injection of ATP (1 mM) was used to activate Vc/C(1-2) neurons. The MAPK/ERK inhibitor (PD98059, 0.01-1 mM) was applied topically to the dorsal Vc/C(1-2) surface at the site of recording 10 min prior to each ATP stimulus. In naïve HE2 rats, low-dose PD98059 caused a maximal inhibition of ATP-evoked activity, whereas even high doses had only minor effects on units in LE2 rats. By contrast, after chronic TMJ inflammation, PD98059 produced a marked and similar dose-related inhibition of ATP-evoked activity in HE2 and LE2 rats. These results suggested that E2 status and chronic inflammation acted, at least in part, through a common MAPK/ERK-dependent signaling pathway to enhance TMJ nociceptive processing by laminae I-II neurons at the spinomedullary junction region.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/estradiol 3-benzoate
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1873-7544
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
29
|
| pubmed:volume |
164
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1813-20
|
| pubmed:dateRevised |
2011-4-28
|
| pubmed:meshHeading |
pubmed-meshheading:19786077-Adenosine Triphosphate,
pubmed-meshheading:19786077-Animals,
pubmed-meshheading:19786077-Chronic Disease,
pubmed-meshheading:19786077-Dose-Response Relationship, Drug,
pubmed-meshheading:19786077-Enzyme Activation,
pubmed-meshheading:19786077-Estradiol,
pubmed-meshheading:19786077-Estrogens,
pubmed-meshheading:19786077-Female,
pubmed-meshheading:19786077-Inflammation,
pubmed-meshheading:19786077-Mitogen-Activated Protein Kinases,
pubmed-meshheading:19786077-Neurons,
pubmed-meshheading:19786077-Ovariectomy,
pubmed-meshheading:19786077-Pain,
pubmed-meshheading:19786077-Rats,
pubmed-meshheading:19786077-Rats, Sprague-Dawley,
pubmed-meshheading:19786077-Signal Transduction,
pubmed-meshheading:19786077-Skin,
pubmed-meshheading:19786077-Temporomandibular Joint,
pubmed-meshheading:19786077-Trigeminal Caudal Nucleus
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Chronic inflammation and estradiol interact through MAPK activation to affect TMJ nociceptive processing by trigeminal caudalis neurons.
|
| pubmed:affiliation |
Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, 18214 Moos Tower, Minneapolis, 515 Delaware Street SE, Minneapolis, MN 55455, USA. tashi004@umn.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|