Source:http://linkedlifedata.com/resource/pubmed/id/19785936
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2010-4-7
|
| pubmed:abstractText |
Transplantation of human endothelial progenitor cells (hEPCs) may improve vascularization and left ventricular function after myocardial infarction. The scope of this study was to explore, whether cross-linking of EPCs may enhance the deposition of cells in the rat heart after clinical-like, intracoronary transplantation. To this end, (111)In-oxinate-labeled hEPCs were infused by a minimally invasive technique into the coronary arteries of immunosuppressed Wistar rats under control conditions and after ischemia/reperfusion. In a second set of experiments hEPCs were treated with phytohemagglutinin to create small cell clusters prior to transplantation. Continous three-dimensional HiSPECT images for 1 h and after 48 h revealed that cell deposition was significantly higher when hEPCs were cross-linked. Therefore, cross-linking of hEPCs may provide a promising approach to enhance the number of trapped cells also in a clinical setting.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1555-3892
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
113-7
|
| pubmed:meshHeading |
pubmed-meshheading:19785936-Animals,
pubmed-meshheading:19785936-Catheterization,
pubmed-meshheading:19785936-Cell Aggregation,
pubmed-meshheading:19785936-Cell Separation,
pubmed-meshheading:19785936-Cell Survival,
pubmed-meshheading:19785936-Cells, Cultured,
pubmed-meshheading:19785936-Coronary Vessels,
pubmed-meshheading:19785936-Endothelial Cells,
pubmed-meshheading:19785936-Graft Survival,
pubmed-meshheading:19785936-Humans,
pubmed-meshheading:19785936-Infusions, Intra-Arterial,
pubmed-meshheading:19785936-Male,
pubmed-meshheading:19785936-Myocardial Infarction,
pubmed-meshheading:19785936-Neovascularization, Physiologic,
pubmed-meshheading:19785936-Phytohemagglutinins,
pubmed-meshheading:19785936-Rats,
pubmed-meshheading:19785936-Rats, Wistar,
pubmed-meshheading:19785936-Reperfusion Injury,
pubmed-meshheading:19785936-Stem Cell Transplantation,
pubmed-meshheading:19785936-Stem Cells,
pubmed-meshheading:19785936-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:19785936-Treatment Outcome
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Cross-linking enhances deposition of human endothelial progenitor cells in the rat heart after intracoronary transplantation.
|
| pubmed:affiliation |
Institute for Cardiovascular Physiology, Heinrich Heine University Duesseldorf, Duesseldorf, Germany. sandra.burghoff@uni-duesseldorf.de
|
| pubmed:publicationType |
Journal Article
|