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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-10-28
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pubmed:abstractText |
Ca(2+)-activated Cl(-) currents (I(Cl(Ca))) in arterial smooth muscle cells are inhibited by phosphorylation. The Ca(2+)-activated Cl(-) channel (Cl(Ca)) blocker niflumic acid (NFA) produces a paradoxical dual effect on I(Cl(Ca)), causing stimulation or inhibition at potentials below or above 0 mV respectively. We tested whether the effects of NFA on I(Cl(Ca)) were modulated by phosphorylation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1476-5381
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
158
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1356-65
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pubmed:dateRevised |
2010-11-2
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pubmed:meshHeading |
pubmed-meshheading:19785656-Adenosine Triphosphate,
pubmed-meshheading:19785656-Animals,
pubmed-meshheading:19785656-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:19785656-Benzylamines,
pubmed-meshheading:19785656-Calcium,
pubmed-meshheading:19785656-Calcium-Calmodulin-Dependent Protein Kinase Type 2,
pubmed-meshheading:19785656-Chloride Channels,
pubmed-meshheading:19785656-Myocytes, Smooth Muscle,
pubmed-meshheading:19785656-Niflumic Acid,
pubmed-meshheading:19785656-Patch-Clamp Techniques,
pubmed-meshheading:19785656-Phosphorylation,
pubmed-meshheading:19785656-Protein Subunits,
pubmed-meshheading:19785656-Pulmonary Artery,
pubmed-meshheading:19785656-Rabbits,
pubmed-meshheading:19785656-Sulfonamides
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pubmed:year |
2009
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pubmed:articleTitle |
Phosphorylation alters the pharmacology of Ca(2+)-activated Cl channels in rabbit pulmonary arterial smooth muscle cells.
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pubmed:affiliation |
Department of Pharmacology, Center of Biomedical Research Excellence (COBRE), University of Nevada School of Medicine, Reno, NV 89557-0270, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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