Linked Life Data

19785608

Source:http://linkedlifedata.com/resource/pubmed/id/19785608

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-11-27
pubmed:abstractText
Sequencing of the human genome has established that our DNA harbours many endogenous retrovirus (ERV) sequences, remnants of ancestral exogenous retroviral infections fixed in the germline DNA. In recent years, human ERVs (HERVs) have been implicated in melanomagenesis. Retrovirus-like particles and the expression of HERV mRNA and proteins have been demonstrated in melanoma tissue. In addition, antibodies to HERV proteins have been observed in patients with melanoma. In vitro and mouse models have provided fascinating insights into the potential mechanisms of HERVs in melanomagenesis. This review considers the evidence associating HERVs with melanoma.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1365-2133
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
161
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1225-31
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The role of human endogenous retroviruses in melanoma.
pubmed:affiliation
Department of Dermatology, Chelsea and Westminster Hospital, Imperial College Faculty of Medicine, London, U.K. saritasingh@doctors.org.uk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't