Source:http://linkedlifedata.com/resource/pubmed/id/19785543
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2009-10-16
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| pubmed:abstractText |
This study investigates the influence of heat stress preconditioning on cognitive outcome for rats with diffuse axonal injury (DAI), and attempts to examine the underlying mechanisms. Wistar rats were divided into four groups: rats subjected to heat stress preconditioning 24 h before induction of DAI (n = 10; HSDAI group), a DAI alone group (n = 10), a heat stress alone group (n = 10), and a sham-injury group (n = 10). From day 14 post-injury, the rats' learning abilities and memory were tested using the Morris water maze (MWM) task, followed by long-term potentiation (LTP) recording of the hippocampus. In addition, hematoxylin and eosin staining (H&E) and immunohistochemical staining (IHC) were conducted to determine the presence of brain lesions and expression of heat shock protein 70 (HSP70) at 24 h, and on days 14 and 20 post-injury. The rats in the DAI group displayed impaired MWM performance and attenuated LTP compared to the sham group (p < 0.05); the rats in the HSDAI and HS groups showed significant improvement in both MWM and LTP compared with the DAI group (p < 0.05), and no significant differences with the sham group (p > 0.05). Following injury, retraction balls, shrunken neurons, and HSP70 expression were visible in the brains of rats from the DAI and HSDAI groups; recovery was expedited in the rats belonging to the HSDAI group, as these pathological changes were alleviated, coincident with higher expression of HSP70. The rats' abilities for learning and memory were impaired following DAI; this may be due to the disconnection of brain regions, damage to neurons in the hippocampus, and a decrease in synaptic plasticity. Heat stress preconditioning is able to significantly attenuate this cognitive impairment, possibly mediated by the neuroprotective effect of HSP70.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1557-9042
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
26
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1695-706
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| pubmed:meshHeading |
pubmed-meshheading:19785543-Animals,
pubmed-meshheading:19785543-Cognition Disorders,
pubmed-meshheading:19785543-Diffuse Axonal Injury,
pubmed-meshheading:19785543-Disease Models, Animal,
pubmed-meshheading:19785543-HSP70 Heat-Shock Proteins,
pubmed-meshheading:19785543-Heat-Shock Proteins,
pubmed-meshheading:19785543-Hippocampus,
pubmed-meshheading:19785543-Immunohistochemistry,
pubmed-meshheading:19785543-Learning Disorders,
pubmed-meshheading:19785543-Long-Term Potentiation,
pubmed-meshheading:19785543-Male,
pubmed-meshheading:19785543-Maze Learning,
pubmed-meshheading:19785543-Memory Disorders,
pubmed-meshheading:19785543-Nerve Degeneration,
pubmed-meshheading:19785543-Neuronal Plasticity,
pubmed-meshheading:19785543-Neuropsychological Tests,
pubmed-meshheading:19785543-Physical Conditioning, Animal,
pubmed-meshheading:19785543-Rats,
pubmed-meshheading:19785543-Rats, Wistar,
pubmed-meshheading:19785543-Staining and Labeling,
pubmed-meshheading:19785543-Stress, Physiological
|
| pubmed:year |
2009
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| pubmed:articleTitle |
Heat stress preconditioning improves cognitive outcome after diffuse axonal injury in rats.
|
| pubmed:affiliation |
School of Medicine, Ministry of Education, College of Life Science, Nankai University, Tianjin, PR China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|