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rdf:type |
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lifeskim:mentions |
umls-concept:C0022116,
umls-concept:C0024485,
umls-concept:C0026845,
umls-concept:C0027651,
umls-concept:C0185125,
umls-concept:C0205210,
umls-concept:C0242411,
umls-concept:C0376261,
umls-concept:C0439064,
umls-concept:C1511790,
umls-concept:C1519249,
umls-concept:C1519355,
umls-concept:C1707391,
umls-concept:C1710020
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pubmed:issue |
6
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pubmed:dateCreated |
2009-11-30
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pubmed:abstractText |
Lactate is an important metabolite in normal and malignant tissues detectable by NMR spectroscopy; however, it has been difficult to clinically detect the lactate methyl resonance because it is obscured by lipid resonances. The selective homonuclear multiple quantum coherence transfer technique offers a method for distinguishing lipid and lactate resonances. We implemented a three-dimensional selective homonuclear multiple quantum coherence transfer version with Hadamard slice selection and two-dimensional phase encoding (Hadamard encoded-selective homonuclear multiple quantum coherence transfer-chemical shift imaging) on a conventional clinical MR scanner. Hadamard slice selection is explained and demonstrated in vivo. This is followed by 1-cm(3) resolution lactate imaging with detection to 5-mM concentration in 20 min on a 3-T clinical scanner. An analysis of QSel gradient duration and amplitude effects on lactate and lipid signal is presented. To demonstrate clinical feasibility, a 5-min lactate scan of a patient with a non-Hodgkin's lymphoma in the superficial thigh is reported. The elevated lactate signal coincides with the T(2)-weighted image of this tumor. As a test of selective homonuclear multiple quantum coherence transfer sensitivity, a thigh tourniquet was applied to a normal volunteer and an increase in lactate was detected immediately after tourniquet flow constriction. In conclusion, the Hadamard encoded-selective homonuclear multiple quantum coherence transfer-chemical shift imaging sequence is demonstrated on a phantom and in two lipid-rich, clinically relevant, in vivo conditions.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/2U24CA083105,
http://linkedlifedata.com/resource/pubmed/grant/F30 NS059116-01A1,
http://linkedlifedata.com/resource/pubmed/grant/F30NS059116,
http://linkedlifedata.com/resource/pubmed/grant/P41 RR002305-23,
http://linkedlifedata.com/resource/pubmed/grant/P41 RR002305-24,
http://linkedlifedata.com/resource/pubmed/grant/P41 RR002305-25,
http://linkedlifedata.com/resource/pubmed/grant/P41 RR002305-25S1,
http://linkedlifedata.com/resource/pubmed/grant/P41 RR002305-26,
http://linkedlifedata.com/resource/pubmed/grant/P41 RR002305-27,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA101700-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA101700-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA101700-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA101700-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA101700-05A2,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA101700-06,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA101700-07,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA102756-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA118559-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01-CA102756,
http://linkedlifedata.com/resource/pubmed/grant/R01CA101700,
http://linkedlifedata.com/resource/pubmed/grant/R01CA118559,
http://linkedlifedata.com/resource/pubmed/grant/R24 CA083105-01,
http://linkedlifedata.com/resource/pubmed/grant/RR02305
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-10371446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-10805885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-11330978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-11818465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-12730951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-12878672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-14512508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-15109009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-15308499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-15488559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-15814918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-1622767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-16678693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-17969083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-18384181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-18666110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-18666182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-19040203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-2266841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-2326464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-3183105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-3938408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-3946620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-7719620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-8025810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-8489495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-8755630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-8875423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-8948348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-9126937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-9387051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19785016-9542740
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1522-2594
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2009 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1404-13
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
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