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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1990-12-14
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pubmed:abstractText |
Variability in the outcome of treatment with antipsychotic drugs may be due to differences in compliance and to variations in pharmacokinetics and concentration-response relationships at the receptor level. Among the various chemical classes of neuroleptics, the butyrophenones, the phenothiazines, and the thioxanthenes have similar pharmacokinetics, and show larger inter-individual variations in plasma drug levels after oral than after intramuscular doses. Compared to the "classical" neuroleptics, the more water-soluble benzamide derivatives have significantly shorter elimination half-lives, and show smaller inter-patient variations in plasma level: dose ratios at steady state.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0065-1591
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
358
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
37-40
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pubmed:dateRevised |
2008-2-15
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pubmed:meshHeading |
pubmed-meshheading:1978485-Antipsychotic Agents,
pubmed-meshheading:1978485-Brain,
pubmed-meshheading:1978485-Dose-Response Relationship, Drug,
pubmed-meshheading:1978485-Humans,
pubmed-meshheading:1978485-Metabolic Clearance Rate,
pubmed-meshheading:1978485-Psychotic Disorders,
pubmed-meshheading:1978485-Receptors, Dopamine,
pubmed-meshheading:1978485-Receptors, Dopamine D2
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pubmed:year |
1990
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pubmed:articleTitle |
Pharmacokinetics of antipsychotic drugs in man.
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pubmed:affiliation |
Institute of Medical Biology, University of Tromsø School of Medicine, Norway.
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pubmed:publicationType |
Journal Article,
Review
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