Linked Life Data

19784796

Source:http://linkedlifedata.com/resource/pubmed/id/19784796

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-1-21
pubmed:abstractText
The presence of activated macrophages is an important predictor of atherosclerotic plaque rupture. In this study, our aim was to determine the accuracy of (18)F- fluorodeoxyglucose (FDG) microPET imaging for quantifying aortic wall macrophage content in a rabbit model of atherosclerosis. Rabbits were divided into a control group and two groups post aortic balloon injury: 6 months high-cholesterol diet (HC); and 3 months HC followed by 3 months low-cholesterol diet plus statin (LCS). In vivo and ex vivo microPET, ex vivo well counting and histological quantification of the atherosclerotic aortas were performed for all groups. Macrophage density was greater in the HC group than the LCS group (5.1 +/- 1.4% vs. 0.6 +/- 0.7%, P < 0.001) with a trend towards greater macrophage density in LCS compared to controls (P = 0.08). There was a strong correlation across all groups between macrophage density and standardized uptake value (SUV) derived from ex vivo microPET (r = 0.95, P < 0.001) and well counting (r = 0.96, P < 0.001). Ex vivo FDG SUV was significantly different between the three groups (P < 0.001). However, the correlation between in vivo microPET FDG SUV and macrophage density was insignificant (r = 0.16, P = 0.57) with no statistical differences in FDG SUV seen between the three groups. This study confirms that in an animal model of inflamed and non-inflamed atherosclerosis, significant differences in FDG SUV allow differentiation of highly inflamed atherosclerotic aortas from those stabilized by statin therapy and low cholesterol diet and controls.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1875-8312
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:19784796-Animals, pubmed-meshheading:19784796-Aorta, pubmed-meshheading:19784796-Atherosclerosis, pubmed-meshheading:19784796-Balloon Dilation, pubmed-meshheading:19784796-Cholesterol, Dietary, pubmed-meshheading:19784796-Diagnosis, Differential, pubmed-meshheading:19784796-Disease Models, Animal, pubmed-meshheading:19784796-Fluorodeoxyglucose F18, pubmed-meshheading:19784796-Heptanoic Acids, pubmed-meshheading:19784796-Hydroxymethylglutaryl-CoA Reductase Inhibitors, pubmed-meshheading:19784796-Inflammation, pubmed-meshheading:19784796-Macrophages, pubmed-meshheading:19784796-Male, pubmed-meshheading:19784796-Positron-Emission Tomography, pubmed-meshheading:19784796-Predictive Value of Tests, pubmed-meshheading:19784796-Pyrroles, pubmed-meshheading:19784796-Rabbits, pubmed-meshheading:19784796-Radiopharmaceuticals
pubmed:year
2010
pubmed:articleTitle
FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis.
pubmed:affiliation
Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't