Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2009-10-20
pubmed:abstractText
The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoic acid (RA) induced early CXCL13 expression in stromal organizer cells independently of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for RA synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to RA receptor (RAR)-dependent induction of CXCL13 in the gut. Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-10192400, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-10336422, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-10839541, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-10875923, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-10917533, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-11245568, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-11359812, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-11509590, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-12077273, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-12479827, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-12669020, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-12702665, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-12732660, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-12732661, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-14691482, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-14975582, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-15311275, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-15322155, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-15470030, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-15611222, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-15753214, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-15780119, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-15832291, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-16025117, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-16543475, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-16751415, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-17110582, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-17273548, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-17291292, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-17304229, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-17322904, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-17452521, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-17512406, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-17521585, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-17569825, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-17907173, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-18349525, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-18396265, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-18403646, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-18542081, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-18852290, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-19079159, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-19140954, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-19380791, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-8171322, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-8855301, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-8978608, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-9128759, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-9354470, http://linkedlifedata.com/resource/pubmed/commentcorrection/19783990-9697837
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1529-2916
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
More...