Linked Life Data

19781985

Source:http://linkedlifedata.com/resource/pubmed/id/19781985

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-11-25
pubmed:abstractText
A primary maternal infection with cytomegalovirus (CMV) either during or just before pregnancy accounts for the majority of congenital infections where the baby is symptomatic at birth. Following a primary maternal infection, depending on gestational age, between one quarter and three quarters of fetuses will become infected, and approximately one-third of infected fetuses will have symptoms at birth. Experiments using animal models of CMV infection and observational studies in humans indicate that administration of a CMV hyperimmune globulin (HIG) to the pregnant woman with a primary CMV infection should be effective for both the treatment and prevention of fetal infection. The HIG probably acts by reducing placental inflammation, neutralizing virus with high avidity antibodies, and perhaps by reducing cytokine mediated cellular immune responses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1873-5967
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
46 Suppl 4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S54-7
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Findings and conclusions from CMV hyperimmune globulin treatment trials.
pubmed:affiliation
Department of Pediatrics, Virginia Commonwealth University, Richmond, 23298, United States. sadler@vcu.edu
pubmed:publicationType
Journal Article, Review