Source:http://linkedlifedata.com/resource/pubmed/id/19780043
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2010-3-17
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| pubmed:abstractText |
Our study investigates the dependence of response monitoring and error detection on genetic influences modulating the serotonergic system. This was done using the event-related potentials (ERPs) after error (Ne/ERN) and correct trials (Nc/CRN). To induce a sufficient amount of errors, a standard flanker task was used. The subjects (N = 94) were genotyped for the functional 5-HT1A C(-1019)G polymorphism. The results show that the 5-HT1A C(-1019)G polymorphism specifically modulates error detection. Neurophysiological modulations on error detection were paralleled by a similar modulation of response slowing after an error, reflecting the behavioral adaptation. The 5-HT1A -1019 CC genotype group showed a larger Ne and stronger posterror slowing than the CG and GG genotype groups. More general processes of performance monitoring, as reflected in the Nc/CRN, were not affected. The finding that error-specific processes, but not general response monitoring processes, are modulated by the 5-HT1A C(-1019)G polymorphism is underlined by a wavelet analysis. In summary, the results suggest a specific effect of the 5-HT1A C(-1019)G polymorphism on error monitoring, as reflected in the Ne, and suggest a neurobiological dissociation between processes of error monitoring and general response monitoring at the level of the serotonin 1A receptor system.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1097-0193
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2009 Wiley-Liss, Inc.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
31
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
621-30
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| pubmed:meshHeading |
pubmed-meshheading:19780043-Adaptation, Psychological,
pubmed-meshheading:19780043-Adult,
pubmed-meshheading:19780043-Brain,
pubmed-meshheading:19780043-Electroencephalography,
pubmed-meshheading:19780043-European Continental Ancestry Group,
pubmed-meshheading:19780043-Evoked Potentials,
pubmed-meshheading:19780043-Executive Function,
pubmed-meshheading:19780043-Feedback, Psychological,
pubmed-meshheading:19780043-Female,
pubmed-meshheading:19780043-Genotype,
pubmed-meshheading:19780043-Humans,
pubmed-meshheading:19780043-Male,
pubmed-meshheading:19780043-Neuropsychological Tests,
pubmed-meshheading:19780043-Polymorphism, Genetic,
pubmed-meshheading:19780043-Psychomotor Performance,
pubmed-meshheading:19780043-Reaction Time,
pubmed-meshheading:19780043-Receptor, Serotonin, 5-HT1A,
pubmed-meshheading:19780043-Sequence Analysis, DNA
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| pubmed:year |
2010
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| pubmed:articleTitle |
Functional 5-HT1a receptor polymorphism selectively modulates error-specific subprocesses of performance monitoring.
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| pubmed:affiliation |
Department of Biopsychology, Institute for Cognitive Neuroscience, Ruhr-Universität Bochum, Germany.
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| pubmed:publicationType |
Journal Article
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