rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2009-10-13
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pubmed:abstractText |
UDP-glucuronosyltransferase (UGT) 2B7 was recently identified as the main enzyme mediating efavirenz N-glucuronidation. In this study, we determined whether selected UGT2B7 polymorphisms could be used to enhance the prediction of efavirenz plasma concentrations from CYP2B6 and CYP2A6 genotypes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoxazines,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronosyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases, N-Demethylating,
http://linkedlifedata.com/resource/pubmed/chemical/Reverse Transcriptase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/S-mephenytoin N-demethylase,
http://linkedlifedata.com/resource/pubmed/chemical/UGT2B7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/coumarin 7-hydroxylase,
http://linkedlifedata.com/resource/pubmed/chemical/efavirenz
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1473-5571
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
23
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2101-6
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pubmed:dateRevised |
2011-5-2
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pubmed:meshHeading |
pubmed-meshheading:19779319-Adult,
pubmed-meshheading:19779319-African Continental Ancestry Group,
pubmed-meshheading:19779319-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:19779319-Benzoxazines,
pubmed-meshheading:19779319-Dose-Response Relationship, Drug,
pubmed-meshheading:19779319-Female,
pubmed-meshheading:19779319-Genotype,
pubmed-meshheading:19779319-Ghana,
pubmed-meshheading:19779319-Glucuronosyltransferase,
pubmed-meshheading:19779319-HIV Infections,
pubmed-meshheading:19779319-Humans,
pubmed-meshheading:19779319-Male,
pubmed-meshheading:19779319-Oxidoreductases, N-Demethylating,
pubmed-meshheading:19779319-Polymorphism, Single Nucleotide,
pubmed-meshheading:19779319-Predictive Value of Tests,
pubmed-meshheading:19779319-Reverse Transcriptase Inhibitors
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pubmed:year |
2009
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pubmed:articleTitle |
CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients.
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pubmed:affiliation |
Warren Alpert Medical School of Brown University, Rhode Island, USA. akwara@lifespan.org
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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