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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5955
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pubmed:dateCreated |
2009-12-7
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pubmed:abstractText |
Amyloid-beta (Abeta) accumulation in the brain extracellular space is a hallmark of Alzheimer's disease. The factors regulating this process are only partly understood. Abeta aggregation is a concentration-dependent process that is likely responsive to changes in brain interstitial fluid (ISF) levels of Abeta. Using in vivo microdialysis in mice, we found that the amount of ISF Abeta correlated with wakefulness. The amount of ISF Abeta also significantly increased during acute sleep deprivation and during orexin infusion, but decreased with infusion of a dual orexin receptor antagonist. Chronic sleep restriction significantly increased, and a dual orexin receptor antagonist decreased, Abeta plaque formation in amyloid precursor protein transgenic mice. Thus, the sleep-wake cycle and orexin may play a role in the pathogenesis of Alzheimer's disease.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AG025824,
http://linkedlifedata.com/resource/pubmed/grant/AG029524,
http://linkedlifedata.com/resource/pubmed/grant/AG030946,
http://linkedlifedata.com/resource/pubmed/grant/K01 AG029524-03,
http://linkedlifedata.com/resource/pubmed/grant/K23 AG030946-03,
http://linkedlifedata.com/resource/pubmed/grant/MH072525,
http://linkedlifedata.com/resource/pubmed/grant/NS065667,
http://linkedlifedata.com/resource/pubmed/grant/P30 DK056341-09,
http://linkedlifedata.com/resource/pubmed/grant/P30 NS057105,
http://linkedlifedata.com/resource/pubmed/grant/P30 NS057105-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG025824-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH072525-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS065667-02
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/((2R)-2-((1S)-6,7-dimethoxy-1-(2-(4-...,
http://linkedlifedata.com/resource/pubmed/chemical/Acetamides,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Cd200r1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neuropeptide,
http://linkedlifedata.com/resource/pubmed/chemical/orexin receptors,
http://linkedlifedata.com/resource/pubmed/chemical/orexins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
326
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1005-7
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19779148-Acetamides,
pubmed-meshheading:19779148-Alzheimer Disease,
pubmed-meshheading:19779148-Amyloid beta-Peptides,
pubmed-meshheading:19779148-Animals,
pubmed-meshheading:19779148-Antigens, Surface,
pubmed-meshheading:19779148-Circadian Rhythm,
pubmed-meshheading:19779148-Disease Models, Animal,
pubmed-meshheading:19779148-Extracellular Fluid,
pubmed-meshheading:19779148-Female,
pubmed-meshheading:19779148-Hippocampus,
pubmed-meshheading:19779148-Humans,
pubmed-meshheading:19779148-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:19779148-Isoquinolines,
pubmed-meshheading:19779148-Light,
pubmed-meshheading:19779148-Male,
pubmed-meshheading:19779148-Mice,
pubmed-meshheading:19779148-Mice, Inbred C57BL,
pubmed-meshheading:19779148-Mice, Transgenic,
pubmed-meshheading:19779148-Neuropeptides,
pubmed-meshheading:19779148-Receptors, Cell Surface,
pubmed-meshheading:19779148-Receptors, G-Protein-Coupled,
pubmed-meshheading:19779148-Receptors, Neuropeptide,
pubmed-meshheading:19779148-Signal Transduction,
pubmed-meshheading:19779148-Sleep,
pubmed-meshheading:19779148-Sleep Deprivation,
pubmed-meshheading:19779148-Wakefulness
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pubmed:year |
2009
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pubmed:articleTitle |
Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle.
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pubmed:affiliation |
Department of Neurology, Washington University, St. Louis, MO 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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