Source:http://linkedlifedata.com/resource/pubmed/id/19778983
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2009-10-16
|
| pubmed:abstractText |
The long-term benefits of antenatal iron supplementation in child survival are not known. In 1999-2001, 4,926 pregnant women in rural Nepal participated in a cluster-randomized, double-masked, controlled trial involving 4 alternative combinations of micronutrient supplements, each containing vitamin A. The authors examined the impact on birth weight and early infant mortality in comparison with controls, who received vitamin A only. They followed the surviving offspring of these women at approximately age 7 years to study effects of in utero supplementation on survival. Of 4,130 livebirths, 209 infants died in the first 3 months and 8 were lost to follow-up. Of those remaining, 3,761 were followed, 150 died between ages 3 months and 7 years, and 152 were lost to follow-up. Mortality rates per 1,000 child-years from birth to age 7 years differed by maternal supplementation group, as follows: folic acid, 13.4; folic acid-iron, 10.3; folic acid-iron-zinc, 12.0; multiple micronutrients; 14.0; and controls, 15.2. Hazard ratios were 0.90 (95% confidence interval (CI): 0.65, 1.22), 0.69 (95% CI: 0.49, 0.99), 0.80 (95% CI: 0.58, 1.11), and 0.93 (95% CI: 0.66, 1.31), respectively, in the 4 supplementation groups. Maternal iron-folic acid supplementation reduced mortality among these children by 31% between birth and age 7 years. These results provide additional motivation for strengthening antenatal iron-folic acid programs.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Folic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/Micronutrients,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin A,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1476-6256
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
170
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1127-36
|
| pubmed:dateRevised |
2010-11-2
|
| pubmed:meshHeading |
pubmed-meshheading:19778983-Body Weights and Measures,
pubmed-meshheading:19778983-Child,
pubmed-meshheading:19778983-Child Mortality,
pubmed-meshheading:19778983-Diet,
pubmed-meshheading:19778983-Dietary Supplements,
pubmed-meshheading:19778983-Double-Blind Method,
pubmed-meshheading:19778983-Female,
pubmed-meshheading:19778983-Folic Acid,
pubmed-meshheading:19778983-Follow-Up Studies,
pubmed-meshheading:19778983-Humans,
pubmed-meshheading:19778983-Iron,
pubmed-meshheading:19778983-Male,
pubmed-meshheading:19778983-Micronutrients,
pubmed-meshheading:19778983-Nepal,
pubmed-meshheading:19778983-Prenatal Care,
pubmed-meshheading:19778983-Prospective Studies,
pubmed-meshheading:19778983-Rural Population,
pubmed-meshheading:19778983-Socioeconomic Factors,
pubmed-meshheading:19778983-Vitamin A,
pubmed-meshheading:19778983-Zinc
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Antenatal and postnatal iron supplementation and childhood mortality in rural Nepal: a prospective follow-up in a randomized, controlled community trial.
|
| pubmed:affiliation |
Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Center for Human Nutrition, Baltimore, Maryland 21205, USA.
|
| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|