Source:http://linkedlifedata.com/resource/pubmed/id/19778566
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2009-12-16
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| pubmed:abstractText |
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is an important regulator and functions negatively in immune response. Its nonsynonymous polymorphism +49G > A (dbSNP: rs231775) has been linked to an elevated risk of T-cell-mediated autoimmune diseases, infectious diseases, and even carcinomas. Here, we examined the genotypes at rs231775 of 1003 subjects in a Han Chinese population to detect the association between this single-nucleotide polymorphism (SNP) and hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) susceptibility, including 375 HBV-related HCC patients, 209 non-HCC patients with HBV infection, and 419 healthy controls. Our results indicated a weak trend for the relationship between rs231775 and HBV-related HCC susceptibility, although the statistical level was not significant. However, a significant difference was identified in males between HBV-related HCC patients and healthy controls. The data revealed that the frequency of the A/A genotype was higher in patients compared with healthy controls (odds ratio [OR] = 1.79, 95% confidence interval [95% CI] 1.05-3.08). The G allele appeared to have a protective effect in developing HBV-related HCC. Subjects with the A allele had higher HCC susceptibility than those with the G allele (OR = 1.31, 95% CI 1.03-1.66). These results suggested that the A/A genotype and A allele of rs231775 increased the risk of developing HBV-related HCC in a male Chinese population.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1879-1166
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
71
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
83-7
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:19778566-Adult,
pubmed-meshheading:19778566-Alleles,
pubmed-meshheading:19778566-Antigens, CD,
pubmed-meshheading:19778566-Asian Continental Ancestry Group,
pubmed-meshheading:19778566-CTLA-4 Antigen,
pubmed-meshheading:19778566-Carcinoma, Hepatocellular,
pubmed-meshheading:19778566-Case-Control Studies,
pubmed-meshheading:19778566-China,
pubmed-meshheading:19778566-Female,
pubmed-meshheading:19778566-Genetic Predisposition to Disease,
pubmed-meshheading:19778566-Genetics, Population,
pubmed-meshheading:19778566-Genotype,
pubmed-meshheading:19778566-Hepatitis B,
pubmed-meshheading:19778566-Humans,
pubmed-meshheading:19778566-Liver Neoplasms,
pubmed-meshheading:19778566-Male,
pubmed-meshheading:19778566-Middle Aged,
pubmed-meshheading:19778566-Polymorphism, Single Nucleotide,
pubmed-meshheading:19778566-Risk Factors,
pubmed-meshheading:19778566-Sex Factors
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
+49G > A polymorphism in the cytotoxic T-lymphocyte antigen-4 gene increases susceptibility to hepatitis B-related hepatocellular carcinoma in a male Chinese population.
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| pubmed:affiliation |
Department of Laboratory Medicine, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai 200438, People's Republic of China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|