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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-10-14
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pubmed:abstractText |
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase involved in multiple intracellular signaling pathways promoting tumor growth. mTOR is aberrantly activated in a significant portion of breast cancers and is a promising target for treatment. Rapamycin and its analogues are in clinical trials for breast cancer treatment. Patterns of gene expression (metagenes) may also be used to simulate a biologic process or effects of a drug treatment. In this study, we tested the hypothesis that the gene-expression signature regulated by rapamycin could predict disease outcome for patients with breast cancer.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1476-4598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
75
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:19778445-Animals,
pubmed-meshheading:19778445-Antibiotics, Antineoplastic,
pubmed-meshheading:19778445-Breast Neoplasms,
pubmed-meshheading:19778445-Cell Line, Tumor,
pubmed-meshheading:19778445-Cell Proliferation,
pubmed-meshheading:19778445-Dose-Response Relationship, Drug,
pubmed-meshheading:19778445-Female,
pubmed-meshheading:19778445-Gene Expression Profiling,
pubmed-meshheading:19778445-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19778445-Humans,
pubmed-meshheading:19778445-Mammary Neoplasms, Experimental,
pubmed-meshheading:19778445-Mice,
pubmed-meshheading:19778445-Mice, Nude,
pubmed-meshheading:19778445-Prognosis,
pubmed-meshheading:19778445-Proportional Hazards Models,
pubmed-meshheading:19778445-Sirolimus,
pubmed-meshheading:19778445-Survival Analysis,
pubmed-meshheading:19778445-Time Factors,
pubmed-meshheading:19778445-Tumor Stem Cell Assay,
pubmed-meshheading:19778445-Xenograft Model Antitumor Assays
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pubmed:year |
2009
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pubmed:articleTitle |
The rapamycin-regulated gene expression signature determines prognosis for breast cancer.
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pubmed:affiliation |
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. aakcakanat@mdanderson.org
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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