Linked Life Data

19778068

Source:http://linkedlifedata.com/resource/pubmed/id/19778068

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2009-10-23
pubmed:abstractText
The known phenanthrenone trigonostemone (1), along with a new phenanthrenone, 9-O-demethyltrigonostemone (2), and two new phenanthropolones, 3,6,9-trimethoxyphenanthropolone (3) and 4,6,9-trimethoxyphenanthropolone (4), were isolated from the roots of Strophioblachia fimbricalyx. Compound 2 showed cytotoxicity against NCI-H187, KB, and MCF7 cancer cells with IC50 values of 0.8, 0.8, and 2.9 microg/mL, respectively, while 3 and 4 showed reduced cytotoxicity. Compounds 2 and 3 displayed antiplasmodial activity in vitro (IC50 values of 2.7 and 3.2 microg/mL, respectively) against Plasmodium falciparum (K1, resistant strain). In addition, the antioxidant activity of 1-4 toward DPPH radicals was determined, but only compound 2 showed any discernible activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1520-6025
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1892-4
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Cytotoxic and antiplasmodial compounds from the roots of Strophioblachia fimbricalyx.
pubmed:affiliation
Department of Chemistry, Faculty of Science, Mahasarakham University, Maha Sarakham 44150, Thailand. prapairat.s@msu.ac.th
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't