Linked Life Data

19776639

Source:http://linkedlifedata.com/resource/pubmed/id/19776639

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-10-15
pubmed:abstractText
Long-chain polyunsaturated fatty acids (LC-PUFAs) play an important role in several physiological processes and their concentration in phospholipids has been associated with several complex diseases, such as atopic disease. The level and composition of LC-PUFAs in the human body is highly dependent on their intake in the diet or on the intake of fatty acid precursors, which are endogenously elongated and desaturated to physiologically active LC-PUFAs. The most important enzymes in this reaction cascade are the Delta(5) and Delta(6) desaturase. Several studies in the last few years have revealed that single nucleotide polymorphisms (SNPs) in the 2 desaturase encoding genes (FADS1 and FADS2) are highly associated with the concentration of omega-6 and omega-3 fatty acids, showing that beside nutrition, genetic factors also play an important role in the regulation of LC-PUFAs. This review focuses on current knowledge of the impact of genetic polymorphisms on LC-PUFA metabolism and on their potential role in the development of atopic diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1661-6499
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2009 S. Karger AG, Basel.
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-28
pubmed:dateRevised
2010-10-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
FADS gene cluster polymorphisms: important modulators of fatty acid levels and their impact on atopic diseases.
pubmed:affiliation
Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, Neuherberg, Germany. eva.lattka@helmholtz-muenchen.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't