Source:http://linkedlifedata.com/resource/pubmed/id/19775845
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-12-7
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| pubmed:abstractText |
Risk factors for imipenem (IMP)-resistant Pseudomonas aeruginosa (IRPA) digestive carriage were analyzed, and genetic events contributing to select resistant isolates in patients exposed to IMP were investigated. Among the 150 patients with hospital-acquired P. aeruginosa digestive carriage, 38 isolates were IRPA. DNA pulsotypes revealed 16 distinct clones. In 4 patients, a second P. aeruginosa isolate showed resistance to IMP compared with the initial susceptible isolate. By comparing the different oprD sequences between IMP-susceptible P. aeruginosa and IRPA strains, a genetic event was systematically found for each resistant isolate, leading to either the absence of OprD or a truncated porin. The multivariate analysis demonstrated that prior IMP exposure was associated with IRPA carriage. In summary, we confirmed that IMP use selects for IRPA in the gut flora. Cross-transmission, however, was frequently observed in intensive care units. Combining epidemiologic approach and molecular analysis is a powerful tool to delineate mechanisms of emerging resistance.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1879-0070
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
66
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1-6
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| pubmed:meshHeading |
pubmed-meshheading:19775845-Adult,
pubmed-meshheading:19775845-Aged,
pubmed-meshheading:19775845-Aged, 80 and over,
pubmed-meshheading:19775845-Anti-Bacterial Agents,
pubmed-meshheading:19775845-Bacterial Proteins,
pubmed-meshheading:19775845-Carrier State,
pubmed-meshheading:19775845-Cohort Studies,
pubmed-meshheading:19775845-Cross Infection,
pubmed-meshheading:19775845-Drug Resistance, Bacterial,
pubmed-meshheading:19775845-Electrophoresis, Gel, Pulsed-Field,
pubmed-meshheading:19775845-Female,
pubmed-meshheading:19775845-Humans,
pubmed-meshheading:19775845-Imipenem,
pubmed-meshheading:19775845-Logistic Models,
pubmed-meshheading:19775845-Male,
pubmed-meshheading:19775845-Microbial Sensitivity Tests,
pubmed-meshheading:19775845-Middle Aged,
pubmed-meshheading:19775845-Porins,
pubmed-meshheading:19775845-Prospective Studies,
pubmed-meshheading:19775845-Pseudomonas aeruginosa,
pubmed-meshheading:19775845-Rectum,
pubmed-meshheading:19775845-Risk Factors
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| pubmed:year |
2010
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| pubmed:articleTitle |
Imipenem-resistant Pseudomonas aeruginosa gastrointestinal carriage among hospitalized patients: risk factors and resistance mechanisms.
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| pubmed:affiliation |
Department of Bacteriology-Hygiene, Nantes University Hospital, France. didier.lepelletier@chu-nantes.fr
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| pubmed:publicationType |
Journal Article
|