| pubmed-article:19773803 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19773803 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19773803 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:19773803 | lifeskim:mentions | umls-concept:C0535025 | lld:lifeskim |
| pubmed-article:19773803 | lifeskim:mentions | umls-concept:C0870071 | lld:lifeskim |
| pubmed-article:19773803 | lifeskim:mentions | umls-concept:C0599278 | lld:lifeskim |
| pubmed-article:19773803 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19773803 | pubmed:dateCreated | 2010-1-4 | lld:pubmed |
| pubmed-article:19773803 | pubmed:abstractText | [(11)C]P943 is a new radioligand recently developed to image and quantify serotonin 5-Hydroxytryptamine (5-HT(1B)) receptors with positron emission tomography (PET). The purpose of this study was to evaluate [(11)C]P943 for this application in humans, and to determine the most suitable quantification method. Positron emission tomography data and arterial input function measurements were acquired in a cohort of 32 human subjects. Using arterial input functions, compartmental modeling, the Logan graphical analysis, and the multilinear method MA1 were tested. Both the two tissue-compartment model and MA1 provided good fits of the PET data and reliable distribution volume estimates. Using the cerebellum as a reference region, BP(ND) binding potential estimates were computed. [(11)C]P943 BP(ND) estimates were significantly correlated with in vitro measurements of the density of 5-HT(1B) receptors, with highest values in the occipital cortex and pallidum. To evaluate noninvasive methods, two- and three-parameter graphical analyses, Simplified Reference Tissue Models (SRTM and SRTM2), and Multilinear Reference Tissue Models (MRTM and MRTM2) were tested. The MRTM2 model provided the best correlation with MA1 binding-potential estimates. Parametric images of the volume of distribution or binding potential of [(11)C]P943 could be computed using both MA1 and MRTM2. The results show that [(11)C]P943 provides quantitative measurements of 5-HT(1B) binding potential. | lld:pubmed |
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| pubmed-article:19773803 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19773803 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19773803 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19773803 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19773803 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19773803 | pubmed:issn | 1559-7016 | lld:pubmed |
| pubmed-article:19773803 | pubmed:author | pubmed-author:HuangYiyunY | lld:pubmed |
| pubmed-article:19773803 | pubmed:author | pubmed-author:DingYu-ShinYS | lld:pubmed |
| pubmed-article:19773803 | pubmed:author | pubmed-author:CarsonRichard... | lld:pubmed |
| pubmed-article:19773803 | pubmed:author | pubmed-author:McCarthyTimot... | lld:pubmed |
| pubmed-article:19773803 | pubmed:author | pubmed-author:NeumeisterAle... | lld:pubmed |
| pubmed-article:19773803 | pubmed:author | pubmed-author:FrostJ... | lld:pubmed |
| pubmed-article:19773803 | pubmed:author | pubmed-author:MaguireR... | lld:pubmed |
| pubmed-article:19773803 | pubmed:author | pubmed-author:KimSunheeS | lld:pubmed |
| pubmed-article:19773803 | pubmed:author | pubmed-author:WilliamsWendo... | lld:pubmed |
| pubmed-article:19773803 | pubmed:author | pubmed-author:TarunSinghalS | lld:pubmed |
| pubmed-article:19773803 | pubmed:author | pubmed-author:GallezotJean-... | lld:pubmed |
| pubmed-article:19773803 | pubmed:author | pubmed-author:Planeta-Wilso... | lld:pubmed |
| pubmed-article:19773803 | pubmed:author | pubmed-author:NabulsiNabeel... | lld:pubmed |
| pubmed-article:19773803 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19773803 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:19773803 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19773803 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19773803 | pubmed:pagination | 196-210 | lld:pubmed |
| pubmed-article:19773803 | pubmed:dateRevised | 2011-7-20 | lld:pubmed |
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| pubmed-article:19773803 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19773803 | pubmed:articleTitle | Kinetic modeling of the serotonin 5-HT(1B) receptor radioligand [(11)C]P943 in humans. | lld:pubmed |
| pubmed-article:19773803 | pubmed:affiliation | PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA. jean-dominique.gallezot@yale.edu | lld:pubmed |
| pubmed-article:19773803 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19773803 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:19773803 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19773803 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19773803 | lld:pubmed |
